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Genetic signature t...
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients
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- Patrick, Matthew T. (author)
- Univ Michigan, MI 48109 USA
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- Stuart, Philip E. (author)
- Univ Michigan, MI 48109 USA
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- Raja, Kalpana (author)
- Univ Michigan, MI 48109 USA; Morgridge Inst Res, WI 53715 USA
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- Gudjonsson, Johann E. (author)
- Univ Michigan, MI 48109 USA
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- Tejasvi, Trilokraj (author)
- Univ Michigan, MI 48109 USA; Ann Arbor Vet Affairs Hosp, MI 48105 USA
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- Yang, Jingjing (author)
- Univ Michigan, MI 48109 USA; Emory Univ, GA 30322 USA
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- Chandran, Vinod (author)
- Univ Toronto, Canada
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- Das, Sayantan (author)
- Univ Michigan, MI 48109 USA
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- Callis-Duffin, Kristina (author)
- Univ Utah, UT 84132 USA
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- Ellinghaus, Eva (author)
- Christian Albrechts Univ Kiel, Germany
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- Enerbäck, Charlotta (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland
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- Esko, Tonu (author)
- Univ Tartu, Estonia; Broad Inst and Harvard, MA 02142 USA
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- Franke, Andre (author)
- Christian Albrechts Univ Kiel, Germany
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- Kang, Hyun M. (author)
- Univ Michigan, MI 48109 USA
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- Krueger, Gerald G. (author)
- Univ Utah, UT 84132 USA
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- Lim, Henry W. (author)
- Henry Ford Hosp, MI 48202 USA
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- Rahman, Proton (author)
- Mem Univ, Canada
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- Rosen, Cheryl F. (author)
- Univ Toronto, Canada
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- Weidinger, Stephan (author)
- Univ Med Ctr Schleswig Holstein, Germany
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- Weichenthal, Michael (author)
- Univ Med Ctr Schleswig Holstein, Germany
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- Wen, Xiaoquan (author)
- Univ Michigan, MI 48109 USA
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- Voorhees, John J. (author)
- Univ Michigan, MI 48109 USA
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- Abecasis, Goncalo R. (author)
- Univ Michigan, MI 48109 USA
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- Gladman, Dafna D. (author)
- Univ Toronto, Canada
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- Nair, Rajan P. (author)
- Univ Michigan, MI 48109 USA
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- Elder, James T. (author)
- Univ Michigan, MI 48109 USA; Ann Arbor Vet Affairs Hosp, MI 48105 USA
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- Tsoi, Lam C. (author)
- Univ Michigan, MI 48105 USA
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(creator_code:org_t)
- 2018-10-09
- 2018
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Psoriatic arthritis (PsA) is a complex chronic musculoskeletal condition that occurs in similar to 30% of psoriasis patients. Currently, no systematic strategy is available that utilizes the differences in genetic architecture between PsA and cutaneous-only psoriasis (PsC) to assess PsA risk before symptoms appear. Here, we introduce a computational pipeline for predicting PsA among psoriasis patients using data from six cohorts with amp;gt;7000 genotyped PsA and PsC patients. We identify 9 new loci for psoriasis or its subtypes and achieve 0.82 area under the receiver operator curve in distinguishing PsA vs. PsC when using 200 genetic markers. Among the top 5% of our PsA prediction we achieve amp;gt;90% precision with 100% specificity and 16% recall for predicting PsA among psoriatic patients, using conditional inference forest or shrinkage discriminant analysis. Combining statistical and machine-learning techniques, we show that the underlying genetic differences between psoriasis subtypes can be used for individualized subtype risk assessment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Patrick, Matthew ...
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Stuart, Philip E ...
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Raja, Kalpana
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Gudjonsson, Joha ...
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Tejasvi, Trilokr ...
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Yang, Jingjing
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show more...
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Chandran, Vinod
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Das, Sayantan
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Callis-Duffin, K ...
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Ellinghaus, Eva
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Enerbäck, Charlo ...
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Esko, Tonu
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Franke, Andre
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Kang, Hyun M.
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Krueger, Gerald ...
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Lim, Henry W.
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Rahman, Proton
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Rosen, Cheryl F.
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Weidinger, Steph ...
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Weichenthal, Mic ...
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Wen, Xiaoquan
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Voorhees, John J ...
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Abecasis, Goncal ...
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Gladman, Dafna D ...
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Nair, Rajan P.
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Elder, James T.
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Tsoi, Lam C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Nature Communica ...
- By the university
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Linköping University