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Patrick, Matthew T.Univ Michigan, MI 48109 USA
(author)
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-10-09
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NATURE PUBLISHING GROUP,2018
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-152385
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-152385URI
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https://doi.org/10.1038/s41467-018-06672-6DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Arthritis National Research Foundation; National Psoriasis Foundation; National Institutes of Health [R01AR042742, R01AR050511, R01AR054966, R01AR063611, R01AR065183, K01AR072129]; Foundation for the National Institutes of Health; Dermatology Foundation; Dawn and Dudley Holmes Foundation; Babcock Memorial Trust; Krembil Foundation; Doris Duke Foundation [2013106]; National Institute of Health [K08AR060802, R01AR06907]; Taubman Medical Research Institute, Frances; Kenneth Eisenberg Emerging Scholar; Ann Arbor Veterans Affairs Hospital
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Psoriatic arthritis (PsA) is a complex chronic musculoskeletal condition that occurs in similar to 30% of psoriasis patients. Currently, no systematic strategy is available that utilizes the differences in genetic architecture between PsA and cutaneous-only psoriasis (PsC) to assess PsA risk before symptoms appear. Here, we introduce a computational pipeline for predicting PsA among psoriasis patients using data from six cohorts with amp;gt;7000 genotyped PsA and PsC patients. We identify 9 new loci for psoriasis or its subtypes and achieve 0.82 area under the receiver operator curve in distinguishing PsA vs. PsC when using 200 genetic markers. Among the top 5% of our PsA prediction we achieve amp;gt;90% precision with 100% specificity and 16% recall for predicting PsA among psoriatic patients, using conditional inference forest or shrinkage discriminant analysis. Combining statistical and machine-learning techniques, we show that the underlying genetic differences between psoriasis subtypes can be used for individualized subtype risk assessment.
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Stuart, Philip E.Univ Michigan, MI 48109 USA
(author)
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Raja, KalpanaUniv Michigan, MI 48109 USA; Morgridge Inst Res, WI 53715 USA
(author)
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Gudjonsson, Johann E.Univ Michigan, MI 48109 USA
(author)
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Tejasvi, TrilokrajUniv Michigan, MI 48109 USA; Ann Arbor Vet Affairs Hosp, MI 48105 USA
(author)
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Yang, JingjingUniv Michigan, MI 48109 USA; Emory Univ, GA 30322 USA
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Chandran, VinodUniv Toronto, Canada
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Das, SayantanUniv Michigan, MI 48109 USA
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Callis-Duffin, KristinaUniv Utah, UT 84132 USA
(author)
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Ellinghaus, EvaChristian Albrechts Univ Kiel, Germany
(author)
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Enerbäck, CharlottaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland(Swepub:liu)chaen00
(author)
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Esko, TonuUniv Tartu, Estonia; Broad Inst and Harvard, MA 02142 USA
(author)
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Franke, AndreChristian Albrechts Univ Kiel, Germany
(author)
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Kang, Hyun M.Univ Michigan, MI 48109 USA
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Krueger, Gerald G.Univ Utah, UT 84132 USA
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Lim, Henry W.Henry Ford Hosp, MI 48202 USA
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Rahman, ProtonMem Univ, Canada
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Rosen, Cheryl F.Univ Toronto, Canada
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Weidinger, StephanUniv Med Ctr Schleswig Holstein, Germany
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Weichenthal, MichaelUniv Med Ctr Schleswig Holstein, Germany
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Wen, XiaoquanUniv Michigan, MI 48109 USA
(author)
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Voorhees, John J.Univ Michigan, MI 48109 USA
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Abecasis, Goncalo R.Univ Michigan, MI 48109 USA
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Gladman, Dafna D.Univ Toronto, Canada
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Nair, Rajan P.Univ Michigan, MI 48109 USA
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Elder, James T.Univ Michigan, MI 48109 USA; Ann Arbor Vet Affairs Hosp, MI 48105 USA
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Tsoi, Lam C.Univ Michigan, MI 48105 USA
(author)
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Univ Michigan, MI 48109 USAUniv Michigan, MI 48109 USA; Morgridge Inst Res, WI 53715 USA
(creator_code:org_t)
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In:Nature Communications: NATURE PUBLISHING GROUP92041-1723
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Patrick, Matthew ...
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Stuart, Philip E ...
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Raja, Kalpana
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Gudjonsson, Joha ...
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Tejasvi, Trilokr ...
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Yang, Jingjing
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Chandran, Vinod
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Das, Sayantan
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Callis-Duffin, K ...
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Ellinghaus, Eva
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Enerbäck, Charlo ...
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Esko, Tonu
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Franke, Andre
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Kang, Hyun M.
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Krueger, Gerald ...
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Lim, Henry W.
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Rahman, Proton
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Rosen, Cheryl F.
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Weidinger, Steph ...
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Weichenthal, Mic ...
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Wen, Xiaoquan
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Voorhees, John J ...
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Abecasis, Goncal ...
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Gladman, Dafna D ...
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Nair, Rajan P.
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Elder, James T.
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Tsoi, Lam C.
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