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Deep TMS of the ins...
Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [C-11] PHNO-PET pilot trial in healthy humans
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- Malik, Saima (author)
- Ctr Addict and Mental Hlth, Canada
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- Jacobs, Mark (author)
- Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada
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- Cho, Sang-Soo (author)
- Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada
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- Boileau, Isabelle (author)
- Ctr Addict and Mental Hlth, Canada
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- Blumberger, Daniel (author)
- Univ Toronto, Canada; Ctr Addict and Mental Hlth, Canada; Ctr Addict and Mental Hlth, Canada
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- Heilig, Markus (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken
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- Wilson, Alan (author)
- Ctr Addict and Mental Hlth, Canada
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- Daskalakis, Zafiris J. (author)
- Univ Toronto, Canada; Ctr Addict and Mental Hlth, Canada; Ctr Addict and Mental Hlth, Canada
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- Strafella, Antonio P. (author)
- Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada; Univ Toronto, Canada; Univ Toronto, Canada
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- Zangen, Abraham (author)
- Ben Gurion Univ Negev, Israel
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- Le Foll, Bernard (author)
- Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict and Mental Hlth, Canada; Ctr Addict and Mental Hlth, Canada
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(creator_code:org_t)
- 2017-11-23
- 2018
- English.
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In: Brain Imaging and Behavior. - : SPRINGER. - 1931-7557 .- 1931-7565. ; 12:5, s. 1306-1317
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Modulating the function of the insular cortex could be a novel therapeutic strategy to treat addiction to a variety of drugs of abuse as this region has been implicated in mediating drug reward and addictive processes. The recent advent of the H-coil has permitted the targeting of deeper brain structures which was not previously feasible. The goal of this study was to bilaterally target the insular region using the H-coil with repetitive Transcranial Magnetic Stimulation (rTMS) and subsequently measure changes in dopamine levels using Positron Emission Tomography (PET) with [11C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO). This was a within-subject, crossover, blinded and sham-controlled pilot study. Eight healthy, right-handed subjects, aged 19-45, participated in the investigation. All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1Hz or 10Hz), on 3 separate days. Low frequency rTMS (1Hz), targeting the insular cortex, significantly decreased dopamine levels in the substantia nigra, sensorimotor striatum and associative striatum. Replicating this study in tobacco smokers or alcoholics would be a logical follow-up to assess whether H-coil stimulation of the bilateral insula can be employed as a treatment option for addiction. Trial registration: NCT02212405
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Insula; PET; Dopamine; H-coil; Deep rTMS; PHNO
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Malik, Saima
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Jacobs, Mark
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Cho, Sang-Soo
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Boileau, Isabell ...
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Blumberger, Dani ...
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Heilig, Markus
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Wilson, Alan
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Daskalakis, Zafi ...
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Strafella, Anton ...
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Zangen, Abraham
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Le Foll, Bernard
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Brain Imaging an ...
- By the university
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Linköping University