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High Keratin 8/18 R...
High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype
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- Golob-Schwarzi, Nicole (author)
- Med Univ Graz, Austria; Ctr Biomaker Res Med, Austria
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- Bettermann, Kira (author)
- Med Univ Graz, Austria
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- Mehta, Anita Kuldeep (author)
- Med Univ Graz, Austria; Dana Farber Canc Inst, MA 02215 USA
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- Kessler, Sonja M. (author)
- Med Univ Graz, Austria; Saarland Univ, Germany
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- Unterluggauer, Julia (author)
- Med Univ Graz, Austria
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- Krassnig, Stefanie (author)
- Med Univ Graz, Austria
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- Kojima, Kensuke (author)
- Univ Texas Southwestern Med Ctr Dallas, TX 75390 USA
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- Chen, Xintong (author)
- Univ Texas Southwestern Med Ctr Dallas, TX 75390 USA
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- Hoshida, Yujin (author)
- Univ Texas Southwestern Med Ctr Dallas, TX 75390 USA
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- Bardeesy, Nabeel M. (author)
- Harvard Med Sch, MA USA
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- Mueller, Heimo (author)
- Med Univ Graz, Austria
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- Svendova, Vendula (author)
- Med Univ Graz, Austria
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- Schimek, Michael G. (author)
- Med Univ Graz, Austria
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- Diwoky, Clemens (author)
- Graz Univ Technol, Austria; Karl Franzens Univ Graz, Austria
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- Lipfert, Alexandra (author)
- Graz Univ Technol, Austria
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- Mahajan, Vineet (author)
- Med Univ Graz, Austria
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- Stumptner, Cornelia (author)
- Med Univ Graz, Austria
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- Thueringer, Andrea (author)
- Med Univ Graz, Austria
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- Froehlich, Leopold F. (author)
- Med Univ Graz, Austria; Univ Munster, Germany
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- Stojakovic, Tatjana (author)
- Med Univ Graz, Austria
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- Nilsson, Peter (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Kolbe, Thomas (author)
- Univ Vet Med Vienna, Austria; Univ Bodenkultur Wien, Austria
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- Ruelicke, Thomas (author)
- Univ Vet Med Vienna, Austria
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- Magin, Thomas M. (author)
- Univ Leipzig, Germany
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- Strnad, Pavel (author)
- Univ Hosp RWTH Aachen, Germany
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- Kiemer, Alexandra K. (author)
- Ctr Biomaker Res Med, Austria
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- Moriggl, Richard (author)
- Univ Vet Med Vienna, Austria; Ludwig Bolzmann Inst Canc Res, Austria; Med Univ Vienna, Austria
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- Haybaeck, Johannes (author)
- Med Univ Graz, Austria; Otto von Guericke Univ, Germany
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2019
- 2019
- English.
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In: Translational Oncology. - : ELSEVIER SCIENCE INC. - 1944-7124 .- 1936-5233. ; 12:2, s. 256-268
- Related links:
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http://urn.kb.se/res...
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND amp; AIMS: Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance. SH is morphologically characterized by steatosis, liver cell ballooning, cytoplasmic aggregates termedMallory-Denk bodies (MDBs), inflammation, and fibrosis at late stage. Disturbance of the keratin cytoskeleton and aggregation of keratins (KRTs) are essential for MDB formation. METHODS: Weanalyzed livers of aged Krt18(-/-) mice that spontaneously developed in the majority of cases SH-associated HCC independent of sex. Interestingly, the hepatic lipid profile in Krt18(-/-) mice, which accumulate KRT8, closely resembles human SH lipid profiles and shows that the excess of KRT8 over KRT18 determines the likelihood to develop SH-associated HCC linked with enhanced lipogenesis. RESULTS: Our analysis of the genetic profile of Krt18(-/-) mice with 26 human hepatoma cell lines and with data sets of amp;gt;300 patients with HCC, where Krt18(-/-) gene signatures matched human HCC. Interestingly, a high KRT8/18 ratio is associated with an aggressive HCC phenotype. CONCLUSIONS: We can prove that intermediate filaments and their binding partners are tightly linked to hepatic lipid metabolism and to hepatocarcinogenesis. We suggest KRT8/18 ratio as a novel HCC biomarker for HCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Golob-Schwarzi, ...
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Bettermann, Kira
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Mehta, Anita Kul ...
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Kessler, Sonja M ...
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Unterluggauer, J ...
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Krassnig, Stefan ...
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show more...
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Kojima, Kensuke
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Chen, Xintong
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Hoshida, Yujin
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Bardeesy, Nabeel ...
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Mueller, Heimo
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Svendova, Vendul ...
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Schimek, Michael ...
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Diwoky, Clemens
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Lipfert, Alexand ...
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Mahajan, Vineet
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Stumptner, Corne ...
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Thueringer, Andr ...
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Froehlich, Leopo ...
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Stojakovic, Tatj ...
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Nilsson, Peter
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Kolbe, Thomas
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Ruelicke, Thomas
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Magin, Thomas M.
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Strnad, Pavel
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Kiemer, Alexandr ...
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Moriggl, Richard
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Haybaeck, Johann ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Translational On ...
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Linköping University