Search: onr:"swepub:oai:DiVA.org:liu-154456" >
AMPA-selective glut...
AMPA-selective glutamate receptor subunits and their relation to glutamate-and GABA-like immunoreactive terminals in the nucleus submedius of the rat
-
- Hamlin, Lina (author)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
-
- Mackerlova, Ludmila, 1945- (author)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
-
- Blomqvist, Anders, 1949- (author)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
-
show more...
-
- Ericson, Ann-Charlott, 1965- (author)
- Linköpings universitet,Cellbiologi,Medicinska fakulteten
-
show less...
-
(creator_code:org_t)
- Elsevier, 1996
- 1996
- English.
-
In: Neuroscience Letters. - : Elsevier. - 0304-3940 .- 1872-7972. ; 217:2-3, s. 149-52
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Glutamate plays an important role in supraspinal nociceptive systems. Thus, glutamate is present in the nucleus submedius of the medial thalamus, a major relay for nociceptive information. In this study, immunoreactivity for the four subunits (GluR1-4) of alpha-amino-3-hydroxy-5-methyl-4-isoxasoleproprionate (AMPA) receptors was examined by a preembedding immunohistochemical method in order to evaluate the presence of this glutamate receptor subtype in the nucleus submedius. Combining the preembedding method with a postembedding immunogold technique, we found that AMPA receptor-like immunoreactivity was present postsynaptically to glutamatergic terminals but not to terminals containing gamma-aminobutyric acid (GABA). These findings suggest a role for AMPA receptors in excitatory synaptic transmission in the nucleus submedius of the rat thalamus.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Receptor
- Glutamate
- Non-N-methyl-d-aspartate
- Pain
- Thalamus
- Electron microscopy
- Postembedding immunohistochemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database