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Phenolic Bis-styryl...
Phenolic Bis-styrylbenzo[c]-1,2,5-thiadiazoles as Probes for Fluorescence Microscopy Mapping of A beta Plaque Heterogeneity
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- Zhang, Jun (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Konsmo, Audun (author)
- Norwegian Univ Sci and Technol, Norway
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- Sandberg, Alexander (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Wu, Xiongyu (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Nyström, Sofie (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Obermuller, Ulrike (author)
- Univ Tubingen, Germany; DZNE German Ctr Neurodegenerat Dis, Germany
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- Wegenast-Braun, Bettina M. (author)
- Univ Tubingen, Germany; DZNE German Ctr Neurodegenerat Dis, Germany
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- Konradsson, Peter (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Lindgren, Mikael (author)
- Norwegian Univ Sci and Technol, Norway
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- Hammarström, Per (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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(creator_code:org_t)
- 2019-02-01
- 2019
- English.
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In: Journal of Medicinal Chemistry. - : AMER CHEMICAL SOC. - 0022-2623 .- 1520-4804. ; 62:4, s. 2038-2048
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- A fluorescent bis-styryl-benzothiadiazole (BTD) with carboxylic acid functional groups (X-34/Congo red analogue) showed lower binding affinity toward A beta 1-42 and A beta 1-40 fibrils than its neutral analogue. Hence, variable patterns of neutral OH-substituted bis-styryl-BTDs were generated. All bis-styryl-BTDs showed higher binding affinity to A beta 1-42 fibrils than to A beta 1-40 fibrils. The para-OH on the phenyl rings was beneficial for binding affinity while a meta-OH decreased the affinity. Differential staining of transgenic mouse A beta amyloid plaque cores compared to peripheral coronas using neutral compared to anionic bis-styryl ligands indicate differential recognition of amyloid polymorphs. Hyperspectral imaging of transgenic mouse A beta plaque stained with uncharged para-hydroxyl substituted bis-styryl-BTD implicated differences in binding site polarity of polymorphic amyloid plaque. Most properties of the corresponding bis-styryl-BTD were retained with a rigid alkyne linker rendering a probe insensitive to cis trans isomerization. These new BTDbased ligands are promising probes for spectral imaging of different A beta fibril polymorphs.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhang, Jun
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Konsmo, Audun
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Sandberg, Alexan ...
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Wu, Xiongyu
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Nyström, Sofie
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Obermuller, Ulri ...
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show more...
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Wegenast-Braun, ...
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Konradsson, Pete ...
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Lindgren, Mikael
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Hammarström, Per
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
- Articles in the publication
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Journal of Medic ...
- By the university
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Linköping University