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  • Andersson, MagnusLinköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska fakulteten (author)

Characterization and estimation of turbulence-related wall shear stress in patient-specific pulsatile blood flow

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • ELSEVIER SCI LTD,2019
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:liu-156101
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-156101URI
  • https://doi.org/10.1016/j.jbiomech.2019.01.016DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Disturbed, turbulent-like blood flow promotes chaotic wall shear stress (WSS) environments, impairing essential endothelial functions and increasing the susceptibility and progression of vascular diseases. These flow characteristics are today frequently detected at various anatomical, lesion and intervention-related sites, while their role as a pathological determinant is less understood. To present-day, numerous WSS-based descriptors have been proposed to characterize the spatiotemporal nature of the WSS disturbances, however, without differentiation between physiological laminar oscillations and turbulence-related WSS (tWSS) fluctuations. Also, much attention has been focused on magnetic resonance (MR) WSS estimations, so far with limited success; promoting the need of a near-wall surrogate marker. In this study, a new approach is explored to characterize the tWSS, by taking advantage of the tensor characteristics of the fluctuating WSS correlations, providing both a magnitude and an anisotropy measure of the disturbances. These parameters were studied in two patient-specific coarctation models (sever and mild), using large eddy simulations, and correlated against near-wall reciprocal Reynolds stress parameters. Collectively, results showed distinct regions of differing tWSS characteristics, features which were sensitive to changes in flow conditions. Generally, the post-stenotic tWSS was governed by near axisymmetric fluctuations, findings that where not consistent with conventional WSS disturbance predictors. At the 2-3 mm wall-offset range, a strong linear correlation was found between tWSS magnitude and near-wall turbulence kinetic energy (TKE), in contrast to the anisotropy indices, suggesting that MR-measured TKE can be used to assess elevated tWSS regions while tWSS anisotropy estimates request well-resolved simulation methods. (C) 2019 Elsevier Ltd. All rights reserved.

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  • Ebbers, TinoLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)tineb49 (author)
  • Karlsson, MattsLinköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)matka16 (author)
  • Linköpings universitetMekanisk värmeteori och strömningslära (creator_code:org_t)

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  • In:Journal of Biomechanics: ELSEVIER SCI LTD85, s. 108-1170021-92901873-2380

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