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Improving Assessmen...
Improving Assessments of Hemodynamics and Vascular Disease
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- Ziegler, Magnus, 1990- (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,CMR
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- Dyverfeldt, Petter, 1980- (thesis advisor)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US
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- Ebbers, Tino, Professor, 1972- (thesis advisor)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US
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- Lantz, Jonas, Dr. 1982- (thesis advisor)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten
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- de Muinck, Ebo, Professor, 1957- (thesis advisor)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Kardiologiska kliniken US
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- Carlhäll, Carljohan, Professor, 1973- (thesis advisor)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US
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- Barker, Alex J., Associate Professor (opponent)
- University of Colorado, Denver, Colorado, United States
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(creator_code:org_t)
- ISBN 9789176850985
- Linköping : Linköping University Electronic Press, 2019
- English 64 s.
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Abstract
Subject headings
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- Blood vessels are more than simple pipes, passively enabling blood to pass through them. Their form and function are dynamic, changing with both aging and disease. This process involves a feedback loop wherein changes to the shape of a blood vessel affect the hemodynamics, causing yet more structural adaptation. This feedback loop is driven in part by the hemodynamic forces generated by the blood flow, and the distribution and strength of these forces appear to play a role in the initiation, progression, severity, and the outcome of vascular diseases.Magnetic Resonance Imaging (MRI) offers a unique platform for investigating both the form and function of the vascular system. The form of the vascular system can be examined using MR-based angiography, to generate detailed geometric analyses, or through quantitative techniques for measuring the composition of the vessel wall and atherosclerotic plaques. To complement these analyses, 4D Flow MRI can be used to quantify the functional aspect of the vascular system, by generating a full time-resolved three-dimensional velocity field that represents the blood flow.This thesis aims to develop and evaluate new methods for assessing vascular disease using novel hemodynamic markers generated from 4D Flow MRI and quantitative MRI data towards the larger goal of a more comprehensive non-invasive examination oriented towards vascular disease. In Paper I, we developed and evaluated techniques to quantify flow stasis in abdominal aortic aneurysms to measure this under-explored aspect of aneurysmal hemodynamics. In Paper II, the distribution and intensity of turbulence in the aorta was quantified in both younger and older men to understand how aging changes this aspect of hemodynamics. A method to quantify the stresses generated by turbulence that act on the vessel wall was developed and evaluated using simulated flow data in Paper III, and in Paper V this method was utilized to examine the wall stresses of the carotid artery. The hemodynamics of vascular disease cannot be uncoupled from the anatomical changes the vessel wall undergoes, and therefore Paper IV developed and evaluated a semi-automatic method for quantifying several aspects of vessel wall composition. These developments, taken together, help generate more valuable information from imaging data, and can be pooled together with other methods to form a more comprehensive non-invasive examination for vascular disease.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Publication and Content Type
- vet (subject category)
- dok (subject category)
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Ziegler, Magnus, ...
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Dyverfeldt, Pett ...
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Ebbers, Tino, Pr ...
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Lantz, Jonas, Dr ...
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de Muinck, Ebo, ...
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Carlhäll, Carljo ...
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Barker, Alex J., ...
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Image Pr ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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Linköping University