Optical coherence tomography represents a sensitive and reliable tool for routine monitoring of idiopathic intracranial hypertension with and without papilledema

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Huang-Link, YuMin,1962-Linköpings universitet,Medicinska fakulteten,Avdelningen för neuro- och inflammationsvetenskap,Region Östergötland, Neurologiska kliniken i Linköping,Karolinska Inst, Sweden (author)

Optical coherence tomography represents a sensitive and reliable tool for routine monitoring of idiopathic intracranial hypertension with and without papilledema

Article/chapterEnglish2019

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2019-01-20
WILEY,2019
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LIBRIS-ID:oai:DiVA.org:liu-156905
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-156905URI
https://doi.org/10.1111/ene.13893DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:140814876URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies|Faculty of Medicine and Health Sciences at Linkoping University; County Council of Ostergotland; Linkoping University Hospital
Background and purpose We previously reported that certain optical coherence tomography (OCT) measures were sensitive and reliable in identifying idiopathic intracranial hypertension (IIH). This prospective study aimed to define OCT measures that allow differentiation of IIH with and without papilledema, thereby helping clinical decision-making. Methods Eight patients with IIH with papilledema, nine without papilledema and 19 with other neurological diseases were included. OCT measures were obtained before lumbar puncture and within 2 h, 1, 3 and 6 months after lumbar puncture with cerebrospinal fluid (CSF) removal. Results All patients with papilledema had increased retinal nerve fiber layer (RNFL) thickness and elevated CSF pressure. All patients without papilledema had normal RNFL but elevated CSF pressure. After CSF removal, reduced RNFL thickness was registered in all eight patients with IIH with papilledema. No significant change in RNFL thickness after CSF removal was observed in IIH without papilledema or in patients with other neurological diseases, although reduced CSF pressure was documented. RNFL thickness tended to be normal in patients with IIH with papilledema at 3-6 months after CSF removal. All patients with IIH showed increased rim area and rim thickness, but reduced optic cup volume regardless of RNFL thickness or papilledema. Conclusions Retinal nerve fiber layer thickness is sensitive for monitoring acute IIH and evaluating treatment effect. Increased rim area and rim thickness and decreased optic cup volume are reliable parameters that indicate persistently increased CSF pressure and risk of relapse. OCT measures are sensitive and reliable for diagnosing subtle IIH even in the absence of papilledema.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
cerebrospinal fluid pressure; cerebrospinal fluid removal; idiopathic intracranial hypertension; lumbar puncture; optical coherence tomography; papilledema

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Eleftheriou, AndreasLinköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)n/a (author)
Yang, G.Southern Med Univ, Peoples R China (author)
Johansson, J. M.Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Ögonkliniken US(Swepub:liu)n/a (author)
Apostolou, AlexandrosLinköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)n/a (author)
Link, H.Karolinska Inst, Sweden (author)
Jin, Y-PUniv Toronto, Canada (author)
Linköpings universitetMedicinska fakulteten (creator_code:org_t)

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In:European Journal of Neurology: WILEY26:5, s. 808-+1351-51011468-1331

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