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Skin microdialysis:...
Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
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- Baumann, Katrine Y. (author)
- RefLab ApS, Denmark; Univ Copenhagen, Denmark
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- Church, Martin K. (author)
- Charite Univ Med Berlin, Germany
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- Clough, Geraldine F. (author)
- Univ Southampton, England
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- Quist, Sven Roy (author)
- Otto von Guericke Univ, Germany; Skin Ctr MDZ, Germany
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- Schmelz, Martin (author)
- Heidelberg Univ, Germany
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- Skov, Per Stahl (author)
- Odense Univ Hosp, Denmark
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- Anderson, Chris (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland
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- Tannert, Line Kring (author)
- Odense Univ Hosp, Denmark
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- Gimenez-Arnau, Ana Maria (author)
- Univ Autonoma Barcelona, Spain
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- Frischbutter, Stefan (author)
- Charite Univ Med Berlin, Germany
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- Scheffel, Joerg (author)
- Charite Univ Med Berlin, Germany
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- Maurer, Marcus (author)
- Charite Univ Med Berlin, Germany
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(creator_code:org_t)
- 2019-04-10
- 2019
- English.
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In: Clinical and Translational Allergy. - : BMC. - 2045-7022. ; 9
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://ctajournal.b...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Microdialysis; Cutaneous; Inflammation; Interstitial; Dermal
Publication and Content Type
- ref (subject category)
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Baumann, Katrine ...
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Church, Martin K ...
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Clough, Geraldin ...
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Quist, Sven Roy
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Schmelz, Martin
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Skov, Per Stahl
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show more...
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Anderson, Chris
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Tannert, Line Kr ...
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Gimenez-Arnau, A ...
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Frischbutter, St ...
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Scheffel, Joerg
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Maurer, Marcus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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Clinical and Tra ...
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Linköping University