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Peripheral Nerve Re...
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression
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- Goncalves, Nadia P. (author)
- Aarhus Univ, Denmark; Aarhus Univ Hosp, Denmark
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- Mohseni, Simin (author)
- Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten
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- El Soury, Marwa (author)
- Univ Turin, Italy
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- Ulrichsen, Maj (author)
- Aarhus Univ, Denmark
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- Richner, Mette (author)
- Aarhus Univ, Denmark
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- Xiao, Junhua (author)
- Univ Melbourne, Australia
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- Wood, Rhiannon J. (author)
- Univ Melbourne, Australia
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- Andersen, Olav M. (author)
- Aarhus Univ, Denmark
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- Coulson, Elizabeth J. (author)
- Univ Queensland, Australia
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- Raimondo, Stefania (author)
- Univ Melbourne, Australia
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- Murray, Simon S. (author)
- Univ Melbourne, Australia
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- Vaegter, Christian B. (author)
- Aarhus Univ, Denmark; Aarhus Univ Hosp, Denmark
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(creator_code:org_t)
- 2019-05-29
- 2019
- English.
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In: Frontiers in Cellular Neuroscience. - : FRONTIERS MEDIA SA. - 1662-5102. ; 13
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur following injury to peripheral nerves. The neurotrophin receptor p75(NTR) has been identified as a positive modulator for Schwann cell myelination during development and implicated in promoting nerve regeneration after injury. However, most studies base this conclusion on results obtained from complete p75(NTR) knockout mouse models and cannot dissect the specific role of p75(NTR) expressed by Schwann cells. In this present study, a conditional knockout model selectively deleting p75(NTR) expression in Schwann cells was generated, where p75(NTR) expression is replaced with that of an mCherry reporter. Silencing of Schwann cell p75(NTR) expression was confirmed in the sciatic nerve in vivo and in vitro, without altering axonal expression of p75(NTR). No difference in sciatic nerve myelination during development or following sciatic nerve crush injury was observed, as determined by quantification of both myelinated and unmyelinated nerve fiber densities, myelinated axonal diameter and myelin thickness. However, the absence of Schwann cell p75(NTR) reduced motor nerve conduction velocity after crush injury. Our data indicate that the absence of Schwann cell p75(NTR) expression in vivo is not critical for axonal regrowth or remyelination following sciatic nerve crush injury, but does play a key role in functional recovery. Overall, this represents the first step in redefining the role of p75(NTR) in the peripheral nervous system, suggesting that the Schwann cell-axon unit functions as a syncytium, with the previous published involvement of p75(NTR) in remyelination most likely depending on axonal/neuronal p75(NTR) and/or mutual glial-axonal interactions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Schwann cells; p75(NTR); myelination; regeneration; nerve injury
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Goncalves, Nadia ...
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Mohseni, Simin
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El Soury, Marwa
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Ulrichsen, Maj
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Richner, Mette
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Xiao, Junhua
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Wood, Rhiannon J ...
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Andersen, Olav M ...
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Coulson, Elizabe ...
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Raimondo, Stefan ...
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Murray, Simon S.
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Vaegter, Christi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Frontiers in Cel ...
- By the university
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Linköping University