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The Tcf21 lineage c...
The Tcf21 lineage constitutes the lung lipofibroblast population
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- Park, Juwon (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Ivey, Malina J. (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Deana, Yanik (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Riggsbee, Kara L. (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Sörensen, Emelie (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Schwabl, Veronika (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Sjöberg, Caroline (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Hjertberg, Tilda (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Park, Ga Young (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Swonger, Jessica M. (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Rosengreen, Taylor (author)
- Univ Hawaii Manoa, HI 96813 USA
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- Morty, Rory E. (author)
- Max Planck Inst Heart and Lung Res, Germany
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- Ahlbrecht, Ekatrin (author)
- Max Planck Inst Heart and Lung Res, Germany
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- Tallquist, Michelle D. (author)
- Univ Hawaii Manoa, HI 96813 USA
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(creator_code:org_t)
- AMER PHYSIOLOGICAL SOC, 2019
- 2019
- English.
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In: American Journal of Physiology - Lung cellular and Molecular Physiology. - : AMER PHYSIOLOGICAL SOC. - 1040-0605 .- 1522-1504. ; 316:5, s. L872-L885
- Related links:
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https://journals.phy...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Transcription factor 21 (Tcf21) is a basic helix-loop-helix transcription factor required for mesenchymal development in several organs. Others have demonstrated that Tcf21 is expressed in embryonic lung mesenchyme and that loss of Tcf21 results in a pulmonary hypoplasia phenotype. Although recent single-cell transcriptome analysis has described multiple mesenchymal cell types in the lung, few have characterized the Tcf21 expressing population. To explore the Tcf21 mesenchymal lineage, we traced Tcf21-expressing cells during embryogenesis and in the adult. Our results showed that Tcf21 progenitor cells at embryonic day (E) 11.5 generated a subpopulation of fibroblasts and lipofibroblasts and a limited number of smooth muscle cells. After E15.5, Tcf21 progenitor cells exclusively become lipofibroblasts and interstitial fibroblasts. Lipid metabolism genes were highly expressed in perinatal and adult Tcf21 lineage cells. Overexpression of Tcf21 in primary neonatal lung fibroblasts led to increases in intracellular neutral lipids, suggesting a regulatory role for Tcf21 in lipofibroblast function. Collectively, our results reveal that Tcf21 expression after E15.5 delineates the lipofibroblast and a population of interstitial fibroblasts. The Tcf21 inducible Cre mouse line provides a novel method for identifying and manipulating the lipofibroblast.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- fibroblast; lipofibroblast; lung; perilipin 2; transcription factor 21
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Park, Juwon
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Ivey, Malina J.
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Deana, Yanik
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Riggsbee, Kara L ...
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Sörensen, Emelie
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Schwabl, Veronik ...
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show more...
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Sjöberg, Carolin ...
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Hjertberg, Tilda
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Park, Ga Young
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Swonger, Jessica ...
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Rosengreen, Tayl ...
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Morty, Rory E.
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Ahlbrecht, Ekatr ...
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Tallquist, Miche ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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American Journal ...
- By the university
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Linköping University