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  • Lange, C.Karolinska Institutet,Res Ctr Borstel, Germany; Univ Lubeck, Germany; German Ctr Infect Res DZIF, Germany; Karolinska Inst, Sweden (author)

Management of patients with multidrug-resistant tuberculosis

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D),2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-159275
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159275URI
  • https://doi.org/10.5588/ijtld.18.0622DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141411425URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|German Center for Infection Research (DZIF); Swedish Heart and Lung Foundation; Swedish Research Council; South African Medical Research Council; European Union (EDCTP)
  • The emergence of multidrug-resistant tuberculosis (MDR-TB; defined as resistance to at least rifampicin and isoniazid) represents a growing threat to public health and economic growth. Never before in the history of mankind have more patients been affected by MDR-TB than is the case today. The World Health Organization reports that MDR-TB outcomes are poor despite staggeringly high management costs. Moreover, treatment is prolonged, adverse events are common, and the majority of affected patients do not receive adequate treatment. As MDR-TB strains are often resistant to one or more second-line anti-TB drugs, in-depth genotypic and phenotypic drug susceptibility testing is needed to construct personalised treatment regimens to improve treatment outcomes. For the first time in decades, the availability of novel drugs such as bedaquiline allow us to design potent and well-tolerated personalised MDR-TB treatment regimens based solely on oral drugs. In this article, we present management guidance to optimise the diagnosis, algorithm-based treatment, drug dosing and therapeutic drug monitoring, and the management of adverse events and comorbidities, associated with MDR-TB. We also discuss the role of surgery, physiotherapy, rehabilitation, palliative care and smoking cessation in patients with MDR-TB. We hope that incorporating these recommendations into patient care will be helpful in optimising treatment outcomes, and lead to more MDR-TB patients achieving a relapse-free cure.

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  • Aarnoutse, R. E.Radboud Univ Nijmegen, Netherlands,Otto Wagner Hosp Vienna, Austria (author)
  • Alffenaar, J. W. C.Univ Groningen, Netherlands,Ctr Hosp Leiria, Portugal; Ctr Innovat Technol and Hlth Care, Portugal (author)
  • Bothamley, G.Homerton Univ Hosp, England; QMUL, England; London Sch Hyg and Trop Med, England (author)
  • Brinkmann, F.Ruhr Univ Bochum, Germany (author)
  • Costa, J.Ctr Hosp Leiria, Portugal; Ctr Innovat Technol and Hlth Care, Portugal (author)
  • Chesov, D.Nicoale Testemitanu State Univ Med and Pharm, Moldova; Res Ctr Borstel, Germany (author)
  • van Crevel, R.Radboud Univ Nijmegen, Netherlands; Univ Oxford, England (author)
  • Dedicoat, M.Univ Hosp Birmingham, England (author)
  • Dominguez, J.Univ Autonoma Barcelona, Spain (author)
  • Duarte, R.Portuguese Natl TB Program, Portugal; Ctr Hosp Vila Nova de Gaia, Portugal; Univ Porto, Portugal; Univ Porto, Portugal (author)
  • Grobbel, H. P.Res Ctr Borstel, Germany; Univ Lubeck, Germany; German Ctr Infect Res DZIF, Germany (author)
  • Guenther, G.Res Ctr Borstel, Germany; Univ Namibia, Namibia,St Petersburg State Res Inst Phthisiopulmonol, Russia (author)
  • Guglielmetti, L.Hop Univ Pitie Salpetriere Charles Foix, France; Univ Pierre and Marie Curie 06, France (author)
  • Heyckendorf, J.Res Ctr Borstel, Germany; Univ Lubeck, Germany; German Ctr Infect Res DZIF, Germany (author)
  • Kay, A. W.Texas Childrens Hosp, TX 77030 USA; Baylor Coll Med, TX 77030 USA; Baylor Coll Med Childrens Fdn, Swaziland (author)
  • Kirakosyan, O.MSF France OCP, Armenia (author)
  • Kirk, O.Univ Copenhagen, Denmark; Univ Southern Denmark, Denmark (author)
  • Koczulla, R. A.Philipps Univ Marburg, Germany; German Ctr Lung Res DZL, Germany (author)
  • Kudriashov, G. G.St Petersburg State Res Inst Phthisiopulmonol, Russia (author)
  • Kuksa, L.Riga East Univ Hosp, Latvia; Riga Stradins Univ, Latvia (author)
  • van Leth, F.Univ Amsterdam, Netherlands (author)
  • Magis-Escurra, C.Radboud Univ Nijmegen, Netherlands (author)
  • Mandalakas, A. M.Texas Childrens Hosp, TX 77030 USA; Baylor Coll Med, TX 77030 USA (author)
  • Molina-Moya, B.Univ Autonoma Barcelona, Spain (author)
  • Peloquin, C. A.Univ Florida, FL USA (author)
  • Reimann, M.Res Ctr Borstel, Germany; Univ Lubeck, Germany; German Ctr Infect Res DZIF, Germany (author)
  • Rumetshofer, R.Otto Wagner Hosp Vienna, Austria (author)
  • Schaaf, H. S.Stellenbosch Univ, South Africa (author)
  • Schön, ThomasLinköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Kalmar Cty Hosp, Sweden(Swepub:liu)thosc49 (author)
  • Tiberi, S.Barts Hlth NHS Trust, England; Queen Mary Univ, England (author)
  • Valda, J.Otto Wagner Hosp Vienna, Austria (author)
  • Yablonskii, P. K.St Petersburg State Res Inst Phthisiopulmonol, Russia; St Petersburg State Univ, Russia (author)
  • Dheda, K.Univ Cape Town, South Africa (author)
  • Karolinska InstitutetRes Ctr Borstel, Germany; Univ Lubeck, Germany; German Ctr Infect Res DZIF, Germany; Karolinska Inst, Sweden (creator_code:org_t)

Related titles

  • In:The International Journal of Tuberculosis and Lung Disease: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)23:6, s. 645-6621027-37191815-7920

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