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Gene expression across mammalian organ development

Cardoso-Moreira, Margarida (author)
Heidelberg Univ ZMBH, Germany; Univ Lausanne, Switzerland
Halbert, Jean (author)
Univ Lausanne, Switzerland
Valloton, Delphine (author)
Univ Lausanne, Switzerland
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Velten, Britta (author)
European Mol Biol Lab, Germany
Chen, Chunyan (author)
Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
Shao, Yi (author)
Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
Liechti, Angelica (author)
Univ Lausanne, Switzerland
Ascencao, Kelly (author)
Univ Lausanne, Switzerland
Rummel, Coralie (author)
Univ Lausanne, Switzerland
Ovchinnikova, Svetlana (author)
Heidelberg Univ ZMBH, Germany
Mazin, Pavel V. (author)
Skolkovo Inst Sci and Technol, Russia; RAS, Russia; HSE Univ, Russia
Xenarios, Ioannis (author)
Univ Lausanne, Switzerland
Harshman, Keith (author)
Univ Lausanne, Switzerland
Mort, Matthew (author)
Cardiff Univ, Wales
Cooper, David N. (author)
Cardiff Univ, Wales
Sandi, Carmen (author)
Ecole Polytech Fed Lausanne, Switzerland
Soares, Michael J. (author)
Univ Kansas, MO USA; Childrens Mercy, MO USA
Ferreira, Paula G. (author)
Univ Porto, Portugal; Univ Porto, Portugal
Afonso, Sandra (author)
Univ Porto, Portugal
Carneiro, Miguel (author)
Univ Porto, Portugal; Univ Porto, Portugal
Turner, James M. A. (author)
Francis Crick Inst, England
VandeBerg, John L. (author)
Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA
Fallahshahroudi, Amir (author)
Linköpings universitet,Biologi,Tekniska fakulteten
Jensen, Per (author)
Linköpings universitet,Biologi,Tekniska fakulteten
Behr, Ruediger (author)
Leibniz Inst Primate Res DPZ, Germany; DZHK German Ctr Cardiovasc Res, Germany
Lisgo, Steven (author)
Newcastle Univ, England
Lindsay, Susan (author)
Newcastle Univ, England
Khaitovich, Philipp (author)
Skolkovo Inst Sci and Technol, Russia; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
Huber, Wolfgang (author)
European Mol Biol Lab, Germany
Baker, Julie (author)
Stanford Univ, CA 94305 USA
Anders, Simon (author)
Heidelberg Univ ZMBH, Germany
Zhang, Yong E. (author)
Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China
Kaessmann, Henrik (author)
Heidelberg Univ ZMBH, Germany
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 (creator_code:org_t)
2019-06-26
2019
English.
In: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 571:7766, s. 505-
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.

Subject headings

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

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ref (subject category)
art (subject category)

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