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  • Cardoso-Moreira, MargaridaHeidelberg Univ ZMBH, Germany; Univ Lausanne, Switzerland (author)

Gene expression across mammalian organ development

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-06-26
  • NATURE PUBLISHING GROUP,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-159572
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159572URI
  • https://doi.org/10.1038/s41586-019-1338-5DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Maryland Brain Collection Center [MR/R006237/1]; state of Baden-Wurttemberg through bwHPC; German Research Foundation; National Institutes of Health; European Research Council [SFB 1036]; National Natural Science Foundation of China [322206]; Fundacao para a Ciencia e Tecnologia through POPH-QREN [31771410, 91731302]; European Social Fund; Portuguese MCTES [IF/00283/2014/CP1256/CT0012]; Swiss National Science Foundation [615253]; [146474]; [329902]
  • The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Halbert, JeanUniv Lausanne, Switzerland (author)
  • Valloton, DelphineUniv Lausanne, Switzerland (author)
  • Velten, BrittaEuropean Mol Biol Lab, Germany (author)
  • Chen, ChunyanChinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China (author)
  • Shao, YiChinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China (author)
  • Liechti, AngelicaUniv Lausanne, Switzerland (author)
  • Ascencao, KellyUniv Lausanne, Switzerland (author)
  • Rummel, CoralieUniv Lausanne, Switzerland (author)
  • Ovchinnikova, SvetlanaHeidelberg Univ ZMBH, Germany (author)
  • Mazin, Pavel V.Skolkovo Inst Sci and Technol, Russia; RAS, Russia; HSE Univ, Russia (author)
  • Xenarios, IoannisUniv Lausanne, Switzerland (author)
  • Harshman, KeithUniv Lausanne, Switzerland (author)
  • Mort, MatthewCardiff Univ, Wales (author)
  • Cooper, David N.Cardiff Univ, Wales (author)
  • Sandi, CarmenEcole Polytech Fed Lausanne, Switzerland (author)
  • Soares, Michael J.Univ Kansas, MO USA; Childrens Mercy, MO USA (author)
  • Ferreira, Paula G.Univ Porto, Portugal; Univ Porto, Portugal (author)
  • Afonso, SandraUniv Porto, Portugal (author)
  • Carneiro, MiguelUniv Porto, Portugal; Univ Porto, Portugal (author)
  • Turner, James M. A.Francis Crick Inst, England (author)
  • VandeBerg, John L.Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA (author)
  • Fallahshahroudi, AmirLinköpings universitet,Biologi,Tekniska fakulteten(Swepub:liu)amifa49 (author)
  • Jensen, PerLinköpings universitet,Biologi,Tekniska fakulteten(Swepub:liu)perje15 (author)
  • Behr, RuedigerLeibniz Inst Primate Res DPZ, Germany; DZHK German Ctr Cardiovasc Res, Germany (author)
  • Lisgo, StevenNewcastle Univ, England (author)
  • Lindsay, SusanNewcastle Univ, England (author)
  • Khaitovich, PhilippSkolkovo Inst Sci and Technol, Russia; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China (author)
  • Huber, WolfgangEuropean Mol Biol Lab, Germany (author)
  • Baker, JulieStanford Univ, CA 94305 USA (author)
  • Anders, SimonHeidelberg Univ ZMBH, Germany (author)
  • Zhang, Yong E.Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China (author)
  • Kaessmann, HenrikHeidelberg Univ ZMBH, Germany (author)
  • Heidelberg Univ ZMBH, Germany; Univ Lausanne, SwitzerlandUniv Lausanne, Switzerland (creator_code:org_t)

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  • In:Nature: NATURE PUBLISHING GROUP571:7766, s. 505-+0028-08361476-4687

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