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Intratunical inject...
Intratunical injection of stromal vascular fraction prevents fibrosis in a rat model of Peyronies disease
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- Castiglione, Fabio (author)
- Univ Leuven, Belgium; Univ Coll London Hosp, England; IRCCS Osped San Raffaele, Italy
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- Hedlund, Petter (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi,Lund Univ, Sweden
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- Weyne, Emmanuel (author)
- Univ Leuven, Belgium
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- Hakim, Lukman (author)
- Univ Leuven, Belgium; Airlangga Univ, Indonesia
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- Montorsi, Francesco (author)
- IRCCS Osped San Raffaele, Italy
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- Salonia, Andrea (author)
- IRCCS Osped San Raffaele, Italy
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- Bivalacqua, Trinity J. (author)
- Johns Hopkins Med Inst, MD 21205 USA
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- De Ridder, Dirk (author)
- Univ Leuven, Belgium
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- Milenkovic, Uros (author)
- Univ Leuven, Belgium
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- Ralph, David (author)
- Univ Coll London Hosp, England
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- Garaffa, Giulio (author)
- Univ Coll London Hosp, England
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- Muneer, Asif (author)
- Univ Coll London Hosp, England
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- Joniau, Steven (author)
- Univ Leuven, Belgium
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- Albersen, Maarten (author)
- Univ Leuven, Belgium
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(creator_code:org_t)
- 2019-06-02
- 2019
- English.
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In: BJU International. - : WILEY. - 1464-4096 .- 1464-410X. ; 124:2, s. 342-348
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective To investigate whether local injection of autologous adipose stromal vascular fraction (SVF) can prevent the development of fibrosis and elastosis in the tunica albuginea (TA) using a rat model of the acute phase of Peyronies disease (PD). Methods A total of 24 male 12-week-old Sprague-Dawley rats were divided into three equal groups: sham; PD without treatment (transforming growth factor-beta [TGF -beta]); and PD treated with SVF 1 day after disease induction. Sham rats received two injections of vehicle into the TA 1 day apart. TGF -beta rats received TGF- beta 1 injection and injection of vehicle 1 day later. SVF rats received TGF-beta 1 injection, followed by SVF 1 day later. One month after treatment, all rats underwent measurement of intracavernosal pressure and mean arterial pressure during electrostimulation of the cavernous nerve. The rats were then killed and penises were harvested for histology and Western blot analysis. Results Erectile function was moderately reduced in the TGF-beta group and was significantly improved after SVF treatment (P amp;lt; 0.05). PD rats developed areas of fibrosis with a significant upregulation of collagen III, collagen I and elastin protein expression. These fibrotic changes were prevented when treated with SVF. Conclusions Local injection of SVF may represent treatment for the acute phase of PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- sexual dysfunction; penile plaque; adipose stem cell; #Peyronies; #erectiledysfunction
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Castiglione, Fab ...
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Hedlund, Petter
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Weyne, Emmanuel
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Hakim, Lukman
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Montorsi, France ...
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Salonia, Andrea
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show more...
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Bivalacqua, Trin ...
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De Ridder, Dirk
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Milenkovic, Uros
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Ralph, David
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Garaffa, Giulio
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Muneer, Asif
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Joniau, Steven
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Albersen, Maarte ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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BJU Internationa ...
- By the university
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Linköping University