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Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy

Landsend, Erlend C. S. (author)
Oslo Univ Hosp, Norway; Univ Oslo, Norway
Pedersen, Hilde R. (author)
Univ South Fastern Norway, Norway
Utheim, Oygunn A. (author)
Oslo Univ Hosp, Norway; Univ Oslo, Norway
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Rueegg, Corina S. (author)
Oslo Univ Hosp, Norway
Baraas, Rigmor C. (author)
Univ South Fastern Norway, Norway
Lagali, Neil (author)
Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
Bragadottir, Ragnheidur (author)
Oslo Univ Hosp, Norway; Univ Oslo, Norway
Moe, Morten C. (author)
Oslo Univ Hosp, Norway; Univ Oslo, Norway
Utheim, Tor P. (author)
Oslo Univ Hosp, Norway; Stavanger Univ Hosp, Norway; Univ Bergen, Norway; Sorlandet Hosp, Norway
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 (creator_code:org_t)
2019-10-01
2019
English.
In: Investigative Ophthalmology and Visual Science. - : ASSOC RESEARCH VISION OPHTHALMOLOGY INC. - 0146-0404 .- 1552-5783. ; 60:13, s. 4120-4128
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • PURPOSE. To investigate fundus autofluorescence (FAF) and other fundus manifestations in congenital aniridia. METHODS. Fourteen patients with congenital aniridia and 14 age- and sex-matched healthy controls were examined. FAF images were obtained with an ultra-widefield scanning laser ophthalmoscope. FAF intensity was quantified in the macular fovea and in a macular ring surrounding fovea and related to an internal reference within each image. All aniridia patients underwent an ophthalmologic examination, including optical coherence tomography and slitlamp biomicroscopy. RESULTS. Mean age was 28.4 +/- 15.0 years in both the aniridia and control groups. Fovea could be defined by subjective assessment of FAF images in three aniridia patients (21.4%) and in all controls (P = 0.001). Mean ratio between FAF intensity in the macular ring and fovea was 1.01 +/- 0.15 in aniridia versus 1.18 +/- 0.09 in controls (P = 0.034). In aniridia, presence of foveal hypoplasia evaluated by biomicroscopy correlated with lack of foveal appearance by subjective analyses of FAF images (P = 0.031) and observation of nystagmus (P = 0.009). CONCLUSIONS. Aniridia patients present a lower ratio between FAF intensity in the peripheral and central macula than do healthy individuals. Both subjective and objective analyses of FAF images are useful tools in evaluation of foveal hypoplasia in aniridia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

Keyword

aniridia; fundus autofluorescence; macular hypoplasia; optical coherence tomography; widefield imaging

Publication and Content Type

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