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Sedimentation rate and suPAR in relation to disease activity and mortality in patients with tuberculosis
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- Schulman, H. (author)
- Region Östergötland, Infektionskliniken i Östergötland
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- Niward, Katarina (author)
- Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland
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- Abate, E. (author)
- Univ Gondar, Ethiopia; Ethiopian Publ Hlth Inst, Ethiopia
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- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D), 2019
- 2019
- English.
- In: The International Journal of Tuberculosis and Lung Disease. - : INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D). - 1027-3719 .- 1815-7920. ; 23:11, s. 1155-1161
- Journal article (peer-reviewed)
Abstract
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- OBJECTIVE : To investigate how levels of the soluble urokinase plasminogen activator receptor (suPAR) and erythrocyte sedimentation rate (ESR) correlate with disease activity and prognosis in pulmonary tuberculosis (PTB). DESIGN: This was a retrospective analysis of patients with active PTB (n = 500) in Gondar, Ethiopia, for whom the suPAR (n = 301) and ESR (n = 330) were analysed at the start of treatment. Both biomarkers were available for 176 patients. Human immunodeficiency virus (HIV) status, chest X-ray (CXR) findings, classification according to the clinical TBscore and treatment outcome were all recorded. RESULTS : In a multivariable logistic regression analysis adjusted for age, sex and HIV status, surrogate markers of disease activity such as advanced CXR patterns correlated with increased levels of suPAR (adjusted OR [aOR] 8.24, Pamp;lt; 0.001) and of ESR (aOR 1.63, P = 0.030), whereas ESR only correlated significantly with a TBscore amp;gt;6 points. Increased levels of both suPAR and ESR were associated with unsuccessful treatment outcomes (aOR 2.93, P = 0.013; aOR 2.52, P = 0.025). The highest quartile of suPAR (aOR 13.3, P = 0.029) but not ESR levels correlated independently with increased mortality. CONCLUSION: SuPAR and ESR levels correlate with disease activity in PTB; however, the clinical role of these potentially prognostic biomarkers needs to be verified in prospective studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- chest X-ray; TBscore; HIV; outcome; biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Schulman, H.
- Niward, Katarina
- Abate, E.
- Idh, Jonna
- Axenram, P.
- Bornefall, Anna
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- Forsgren, S.
- Jakobsson, J.
- Öhrling, C.
- Kron, M.
- Brudin, Lars
- Diro, E.
- Kebede, A. Getac ...
- Paues, Jakob
- Bruchfeld, J.
- Wejse, C.
- Stendahl, Olle
- Schön, Thomas
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