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Exosome-like nanopl...
Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine
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- Lin, Qing (author)
- Sichuan Univ, Peoples R China; Univ Cambridge, England
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- Qu, Mengke (author)
- Sichuan Univ, Peoples R China
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- Zhou, Bingjie (author)
- Sichuan Univ, Peoples R China
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- Patra, Hirak Kumar (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Univ Cambridge, England
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- Sun, Zihan (author)
- Sichuan Univ, Peoples R China
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- Luo, Qiong (author)
- Sichuan Univ, Peoples R China
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- Yang, Wenyu (author)
- Sichuan Univ, Peoples R China
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- Wu, Yongcui (author)
- Sichuan Univ, Peoples R China
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- Zhang, Yu (author)
- Sichuan Univ, Peoples R China
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- Li, Lin (author)
- Sichuan Univ, Peoples R China
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- Deng, Lang (author)
- Sichuan Univ, Peoples R China
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- Wang, Leilei (author)
- Sichuan Univ, Peoples R China
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- Gong, Tao (author)
- Sichuan Univ, Peoples R China
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- He, Qin (author)
- Sichuan Univ, Peoples R China
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- Zhang, Ling (author)
- Sichuan Univ, Peoples R China
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- Sun, Xun (author)
- Sichuan Univ, Peoples R China
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- Zhang, Zhirong (author)
- Sichuan Univ, Peoples R China
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(creator_code:org_t)
- ELSEVIER, 2019
- 2019
- English.
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In: Journal of Controlled Release. - : ELSEVIER. - 0168-3659 .- 1873-4995. ; 311, s. 104-116
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Currently, most anti-cancer therapies are still haunted by serious and deleterious adverse effects. Here, we report a highly biocompatible tumor cell-targeting delivery systems utilizing exosome-like vesicles (ELVs) that delivers a low-toxicity anti-cancer agent imperialine against non-small cell lung cancer (NSCLC). First, we introduced a novel micelle-aided method to efficiently load imperialine into intact ELVs. Then, integrin alpha 3 beta 1-binding octapeptide cNGQGEQc was modified onto ELV platform for tumor targeting as integrin alpha 3 beta 1 is overexpressed on NSCLC cells. This system not only significantly improved imperialine tumor accumulation and retention, but also had extremely low systemic toxicity both in vitro and in vivo. Our discoveries offer new ways to utilize ELV more efficiently for both drug loading and targeting. The solid pharmacokinetics improvement and extraordinary safety of this system also highlight possibilities of alternative long course cancer therapies using similar strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Exosome-like vesicles; Imperialine; Non-small cell lung cancer; Inflammation; NF-kappa B pathway; Micelle-aided drug loading
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lin, Qing
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Qu, Mengke
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Zhou, Bingjie
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Patra, Hirak Kum ...
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Sun, Zihan
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Luo, Qiong
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show more...
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Yang, Wenyu
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Wu, Yongcui
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Zhang, Yu
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Li, Lin
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Deng, Lang
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Wang, Leilei
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Gong, Tao
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He, Qin
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Zhang, Ling
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Sun, Xun
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Zhang, Zhirong
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Journal of Contr ...
- By the university
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Linköping University