Search: onr:"swepub:oai:DiVA.org:liu-162596" >
Apolipoprotein E ge...
-
Skillbäck, TobiasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
(author)
Apolipoprotein E genotypes and longevity across dementia disorders
- Article/chapterEnglish2018
Publisher, publication year, extent ...
-
2018-03-13
-
Elsevier,2018
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-162596
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-162596URI
-
https://doi.org/10.1016/j.jalz.2018.02.003DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:138698880URI
-
https://lup.lub.lu.se/record/d45e54a9-1660-4eed-8821-f5b4ff7808dfURI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361543URI
-
https://gup.ub.gu.se/publication/265762URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
INTRODUCTION: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied.METHODS: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity.RESULTS: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders.DISCUSSION: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Lautner, RonaldGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlauro
(author)
-
Mattsson, NiklasLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Lund, Sweden,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmö, Sweden; Skåne Univ Hosp, Dept Neurol, Lund, Sweden(Swepub:lu)med-nmn
(author)
-
Schott, Jonathan MDementia Research Centre, UCL Institute of Neurology, London, UK,University College London,UCL Inst Neurol, Dementia Res Ctr, London, England
(author)
-
Skoog, IngmarSahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden,Univ Gothenburg, Neuropsychiat Epidemiol Unit, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Mölndal, Sweden
(author)
-
Nägga, KatarinaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmö, Sweden,Lund University, Malmö, Sweden(Swepub:lu)med-kng
(author)
-
Kilander, LenaUppsala universitet,Uppsala University,Geriatrik,Uppsala University, Uppsala, Sweden(Swepub:uu)lekil226
(author)
-
Wimo, AndersUppsala universitet,Uppsala University,Karolinska Institutet,Centrum för klinisk forskning, Gävleborg,Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden,Karolinska Institutet, Huddinge, Sweden; Uppsala University/County Council of Gävleborg, Gävle, Sweden
(author)
-
Winblad, BengtKarolinska Institutet,Karolinska Institutet, Huddinge, Sweden; Karolinska University Hospital, Huddinge, Sweden,Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden; Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden
(author)
-
Eriksdotter, MariaKarolinska Institutet,Karolinska Institutet, Huddinge, Sweden; Karolinska University Hospital, Huddinge, Sweden,Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden; Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden
(author)
-
Blennow, KajGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
-
Zetterberg, HenrikGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
-
In:Alzheimer's & Dementia: Elsevier14:7, s. 895-9011552-52601552-5279
Internet link
Find in a library
To the university's database
- By the author/editor
-
Skillbäck, Tobia ...
-
Lautner, Ronald
-
Mattsson, Niklas
-
Schott, Jonathan ...
-
Skoog, Ingmar
-
Nägga, Katarina
-
show more...
-
Kilander, Lena
-
Wimo, Anders
-
Winblad, Bengt
-
Eriksdotter, Mar ...
-
Blennow, Kaj
-
Zetterberg, Henr ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Geriatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Alzheimer's & De ...
- By the university
-
Linköping University
-
Karolinska Institutet
-
Lund University
-
Uppsala University
-
University of Gothenburg