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Transcranial Electr...
Transcranial Electrical Stimulation and Recording of Brain Activity using Freestanding Plant-Based Conducting Polymer Hydrogel Composites
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- Spyropoulos, George D. (author)
- Columbia Univ, NY 10027 USA
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- Savarin, Jeremy (author)
- Columbia Univ, NY 10027 USA
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- Gomez, Eliot, 1985- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Simon, Daniel (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Berggren, Magnus (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Gelinas, Jennifer N. (author)
- Columbia Univ, NY 10032 USA
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- Stavrinidou, Eleni (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Khodagholy, Dion (author)
- Columbia Univ, NY 10027 USA
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(creator_code:org_t)
- 2019-12
- 2020
- English.
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In: Advanced Materials Technologies. - : Wiley-VCH Verlagsgesellschaft. - 2365-709X. ; :3
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Transcranial electrical stimulation is a noninvasive neurostimulation technique with a wide range of therapeutic applications. However, current electrode materials are typically not optimized for this abiotic/biotic interface which requires high charge capacity, operational stability, and conformability. Here, a plant-based composite electrode material based on the combination of aloe vera (AV) hydrogel and a conducting polymer (CP; poly(3,4-ethylenedioxythiophene):polystyrene sulfonate, PEDOT:PSS) is reported. This material system is fabricated into films and provides biocompatibility, conformability, and stability, while offering desirable electrical properties of the PEDOT:PSS. AVCP films are also molded onto the rough surface of the skull leading to a mechanically stable and robust interface. The in vivo efficacy of the AVCP films is verified to function as stimulating and recording electrodes by placing them on the skull of a rat and concomitantly inducing focal seizures and acquiring the evoked neural activity. AVCP films pave the way for high-quality biological interfaces that are broadly applicable and can facilitate advances in closed-loop responsive stimulation devices.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Textil-, gummi- och polymermaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Textile, Rubber and Polymeric Materials (hsv//eng)
Keyword
- aloe vera; hydrogel; PEDOT; PSS; transcranial electrical stimulation (TES)
Publication and Content Type
- ref (subject category)
- art (subject category)
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