Allergy development is associated with consumption of breastmilk with a reduced microbial richness in the first month of life

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Dzidic, MajdaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Inst Agrochem and Food Technol IATA CSIC, Spain; FISABIO, Spain (author)

Allergy development is associated with consumption of breastmilk with a reduced microbial richness in the first month of life

Article/chapterEnglish2020

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2019-12-11
WILEY,2020
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-162862
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-162862URI
https://doi.org/10.1111/pai.13176DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding Agencies|Spanish Ministry of Economy and Competitiveness [BIO2015-68711-R]; Swedish Research CouncilSwedish Research Council [2016-01698]; Swedish Heart and Lung FoundationSwedish Heart-Lung Foundation [20140321, 20170365]; Cancer and Allergy Foundation; European Research Council (ERC)European Research Council (ERC)Estonian Research Council [639226]
Background Early colonization with a diverse microbiota seems to play a crucial role for appropriate immune maturation during childhood. Breastmilk microbiota is one important source of microbes for the infant, transferred together with maternal IgA antibodies. We previously observed that allergy development during childhood was associated with aberrant IgA responses to the gut microbiota already at 1 month of age, when the IgA antibodies are predominantly maternally derived in breastfed infants. Objective To determine the microbial composition and IgA-coated bacteria in breastmilk in relation to allergy development in children participating in an intervention trial with pre- and post-natal Lactobacillus reuteri supplementation. Methods A combination of flow cytometric cell sorting and 16S rRNA gene sequencing was used to characterize the bacterial recognition patterns by IgA in breastmilk samples collected one month post-partum from 40 mothers whose children did or did not develop allergic and asthmatic symptoms during the first 7 years of age. Results The milk fed to children developing allergic manifestations had significantly lower bacterial richness, when compared to the milk given to children that remained healthy. Probiotic treatment influenced the breastmilk microbiota composition. However, the proportions of IgA-coated bacteria, the total bacterial load and the patterns of IgA-coating were similar in breastmilk between mothers of healthy children and those developing allergies. Conclusion Consumption of breastmilk with a reduced microbial richness in the first month of life may play an important role in allergy development during childhood.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
allergy; breastmilk; IgA; microbiota; mother-infant transfer

Added entries (persons, corporate bodies, meetings, titles ...)

Mira, AlexFISABIO, Spain; CIBER ESP, Spain (author)
Artacho, AlejandroFISABIO, Spain (author)
Abrahamsson, Thomas,1968-Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus(Swepub:liu)thoab97 (author)
Jenmalm, Maria,1971-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)marje18 (author)
Carmen Collado, MariaInst Agrochem and Food Technol IATA CSIC, Spain (author)
Linköpings universitetAvdelningen för neuro- och inflammationsvetenskap (creator_code:org_t)

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In:Pediatric Allergy and Immunology: WILEY31, s. 250-2570905-61571399-3038

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