Immune Biomarkers for Diagnosis and Treatment Monitoring of Tuberculosis: Current Developments and Future Prospects

Immune Biomarkers for Diagnosis and Treatment Monitoring of Tuberculosis : Current Developments and Future Prospects

Tan, Hong Y. (author): Xiamen Univ Malaysia, Malaysia; Xiamen Univ Malaysia, Malaysia

Larsson, Marie (author): Linköpings universitet,Avdelningen för hematopoes och utvecklingsbiologi,Medicinska fakulteten

(creator_code:org_t)

2019-12-18
2019
English.
In: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 10

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Abstract Subject headings

Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the host biomarkers appears to play a significant role. The currently available diagnostic technology for TB detection is inadequate. Although GeneXpert detects total DNA present in the sample regardless live or dead bacilli present in clinical samples, all the commercial tests available thus far have low sensitivity. Humoral responses against Mycobacterium tuberculosis (Mtb) antigens are generally low, which precludes the use of serological tests for TB diagnosis, prognosis, and treatment monitoring. Mtb-specific CD4(+) T cells correlate with Mtb antigen/bacilli burden and hence might serve as good biomarkers for monitoring treatment progress. Omics-based techniques are capable of providing a more holistic picture for disease mechanisms and are more accurate in predicting TB disease outcomes. The current review aims to discuss some of the recent advances on TB biomarkers, particularly host biomarkers that have the potential to diagnose and differentiate active TB and LTBI as well as their use in disease prognosis and treatment monitoring.

By the author/editor: Yong, Yean K.; Tan, Hong Y.; Saeidi, Alireza; Wong, Won F.; Vignesh, Ramacha ...; Velu, Vijayakuma ...; show more...; Eri, Rajaraman; Larsson, Marie; Shankar, Esaki M ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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