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Human sperm display...
Human sperm displays rapid responses to diet
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- Nätt, Daniel (author)
- Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelning för neurobiologi
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- Örtegren Kugelberg, Unn (author)
- Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelning för neurobiologi
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- Casas, Eduard (author)
- Josep Carreras Leukaemia Res Inst IJC, Spain,Josep Carreras Leukaemia Research Institute (IJC)
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- Nedstrand, Elizabeth (author)
- Linköping University,Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Zalavary, Stefan (author)
- Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelningen för barns och kvinnors hälsa,Region Östergötland, Kvinnokliniken US
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- Henriksson, Pontus (author)
- Linköping University,Karolinska Institute,Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Karolinska Inst, Sweden
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- Nijm, Carola (author)
- Linköping University,Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Jaderquist, Julia (author)
- Linköping University,Karolinska Institutet,Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Sandborg, Johanna (author)
- Linköping University,Karolinska Institute,Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Karolinska Inst, Sweden
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- Flinke Carlsson, Eva (author)
- Linköping University,Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten
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- Ramesh, Rashmi (author)
- Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelning för neurobiologi
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- Örkenby, Lovisa (author)
- Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelning för neurobiologi
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- Appelkvist, Filip (author)
- Linköping University,Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten
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- Lingg, Thomas (author)
- Linköping University,Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten
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- Guzzi, Nicola (author)
- Lund University,Lunds universitet,RNA och stamcellsbiologi,Forskargrupper vid Lunds universitet,RNA and Stem Cell Biology,Lund University Research Groups
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- Bellodi, Cristian (author)
- Lund University,Lunds universitet,RNA och stamcellsbiologi,Forskargrupper vid Lunds universitet,RNA and Stem Cell Biology,Lund University Research Groups
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- Löf, Marie (author)
- Linköping University,Karolinska Institute,Karolinska Institutet,Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Karolinska Inst, Sweden
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- Vavouri, Tanya (author)
- Josep Carreras Leukaemia Res Inst IJC, Spain,Josep Carreras Leukaemia Research Institute (IJC)
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- Öst, Anita (author)
- Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelning för neurobiologi
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(creator_code:org_t)
- 2019-12-26
- 2019
- English.
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In: PLoS biology. - San Francisco, CA United States : PUBLIC LIBRARY SCIENCE. - 1544-9173 .- 1545-7885. ; 17:12
- Related links:
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Abstract
Subject headings
Close
- The global rise in obesity and steady decline in sperm quality are two alarming trends that have emerged during recent decades. In parallel, evidence from model organisms shows that paternal diet can affect offspring metabolic health in a process involving sperm tRNA-derived small RNA (tsRNA). Here, we report that human sperm are acutely sensitive to nutrient flux, both in terms of sperm motility and changes in sperm tsRNA. Over the course of a 2-week diet intervention, in which we first introduced a healthy diet followed by a diet rich in sugar, sperm motility increased and stabilized at high levels. Small RNA-seq on repeatedly sampled sperm from the same individuals revealed that tsRNAs were up-regulated by eating a high-sugar diet for just 1 week. Unsupervised clustering identified two independent pathways for the biogenesis of these tsRNAs: one involving a novel class of fragments with specific cleavage in the T-loop of mature nuclear tRNAs and the other exclusively involving mitochondrial tsRNAs. Mitochondrial involvement was further supported by a similar up-regulation of mitochondrial rRNA-derived small RNA (rsRNA). Notably, the changes in sugar-sensitive tsRNA were positively associated with simultaneous changes in sperm motility and negatively associated with obesity in an independent clinical cohort. This rapid response to a dietary intervention on tsRNA in human sperm is attuned with the paternal intergenerational metabolic responses found in model organisms. More importantly, our findings suggest shared diet-sensitive mechanisms between sperm motility and the biogenesis of tsRNA, which provide novel insights about the interplay between nutrition and male reproductive health.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Nätt, Daniel
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Örtegren Kugelbe ...
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Casas, Eduard
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Nedstrand, Eliza ...
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Zalavary, Stefan
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Henriksson, Pont ...
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show more...
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Nijm, Carola
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Jaderquist, Juli ...
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Sandborg, Johann ...
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Flinke Carlsson, ...
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Ramesh, Rashmi
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Örkenby, Lovisa
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Appelkvist, Fili ...
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Lingg, Thomas
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Guzzi, Nicola
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Bellodi, Cristia ...
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Löf, Marie
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Vavouri, Tanya
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Öst, Anita
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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PLoS biology
- By the university
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Linköping University
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Karolinska Institutet
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Lund University