Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

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Fältnamn	Indikatorer	Metadata
000		07456naa a2200721 4500
001		oai:DiVA.org:liu-163872
003		SwePub
008		200224s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1638722 URI
024	7	a https://doi.org/10.1016/j.biopsych.2019.07.0102 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ousdal, Olga Thereseu Haukeland Hosp, Norway4 aut
245	1 0	a Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
264	1	b Elsevier,c 2020
338		a electronic2 rdacarrier
500		a Funding Agencies\|Western Norway Regional Health Authority [911986, 912238]; University of Bergen; Fulbright Program; National Institute of Mental HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [MH092301, MH110008, U01 MH11826]; Interdisciplinary Center for Clinical Research of the Medical Faculty of Munster [Dan 3/012/17]; Lundbeck FoundationLundbeckfonden; Carlos III Health InstituteInstituto de Salud Carlos III [CPII16/00048]; Innovative Medical Research [RE111604, RE111722, RO1 MH111359, U24 DA041123]; German Research FoundationGerman Research Foundation (DFG) [FOR2107 DA1151/5-1, DA1151/5-2, SFB-TRR58]
520		a BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean +/- SD of 1.04 +/- 1.03% (Cohens d = 1.01, p amp;lt; .001) and the subcortical gray matter volume increased by 1.47 +/- 1.05% (d = 1.40, p amp;lt; .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearmans rank correlation rho = -.44, p amp;lt; .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653		a Antidepressant; Biomarker; Brain; Depression; ECT; Magnetic resonance imaging; Neuroimaging
700	1	a Argyelan, Miklosu Feinstein Inst Med Res, NY USA4 aut
700	1	a Narr, Katherine L.u Univ Calif Los Angeles, CA 90024 USA4 aut
700	1	a Abbott, Christopheru Univ New Mexico, NM 87131 USA4 aut
700	1	a Wade, Benjaminu Univ Calif Los Angeles, CA 90024 USA4 aut
700	1	a Vandenbulcke, Mathieuu Katholieke Univ Leuven, Belgium4 aut
700	1	a Urretavizcaya, Mikelu Univ Barcelona, Spain; Univ Barcelona, Spain; Carlos III Hlth Inst, Spain4 aut
700	1	a Tendolkar, Indirau Radboud Univ Nijmegen, Netherlands; Ctr Cognit Neuroimaging, Netherlands; Univ Duisburg Essen, Germany; Univ Duisburg Essen, Germany4 aut
700	1	a Takamiya, Akihirou Keio Univ, Japan; Komagino Hosp, Japan4 aut
700	1	a Stek, Max L.u Geestelijke GezondheidsZorg InGeest Specialized M, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Soriano-Mas, Carlesu Univ Barcelona, Spain; Univ Autonoma Barcelona, Spain; Carlos III Hlth Inst, Spain4 aut
700	1	a Redlich, Ronnyu Univ Munster, Germany4 aut
700	1	a Paulson, Olaf B.u Rigshosp, Denmark; Univ Copenhagen, Denmark4 aut
700	1	a Oudega, Mardien L.u Geestelijke GezondheidsZorg InGeest Specialized M, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Opel, Nilsu Univ Munster, Germany; Univ Munster, Germany4 aut
700	1	a Nordanskog, Pia,d 1971-u Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping4 aut0 (Swepub:liu)piano33
700	1	a Kishimoto, Taishirou Keio Univ, Japan4 aut
700	1	a Kämpe, Robinu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)robka95
700	1	a Jorgensen, Andersu Rigshosp, Denmark4 aut
700	1	a Hanson, Lars G.u Tech Univ Denmark, Denmark; Copenhagen Univ Hosp, Denmark4 aut
700	1	a Hamilton, Paulu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)pauha77
700	1	a Espinoza, Randallu Univ Calif Los Angeles, CA 90024 USA4 aut
700	1	a Emsell, Louiseu Katholieke Univ Leuven, Belgium4 aut
700	1	a van Eijndhoven, Philipu Radboud Univ Nijmegen, Netherlands; Ctr Cognit Neuroimaging, Netherlands4 aut
700	1	a Dols, Annemiekeu Geestelijke GezondheidsZorg InGeest Specialized M, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Dannlowski, Udou Univ Munster, Germany4 aut
700	1	a Cardoner, Narcisu Univ Autonoma Barcelona, Spain; Carlos III Hlth Inst, Spain; Univ Hosp Parc Tauli I3PT, Spain4 aut
700	1	a Bouckaert, Filipu Katholieke Univ Leuven, Belgium4 aut
700	1	a Anand, Amitu Cleveland Clin, OH 44106 USA4 aut
700	1	a Bartsch, Haukeu Univ Calif Los Angeles, CA USA; Ctr Multimodal Imaging and Genet, CA USA; Univ Calif San Diego, CA 92093 USA4 aut
700	1	a Kessler, Uteu Haukeland Hosp, Norway; Univ Bergen, Norway4 aut
700	1	a Oedegaard, Ketil J.u Haukeland Hosp, Norway; Univ Bergen, Norway4 aut
700	1	a Dale, Anders M.u Univ Calif Los Angeles, CA USA; Ctr Multimodal Imaging and Genet, CA USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA4 aut
700	1	a Oltedal, Leifu Haukeland Hosp, Norway; Univ Bergen, Norway4 aut
710	2	a Haukeland Hosp, Norwayb Feinstein Inst Med Res, NY USA4 org
773	0	t Biological Psychiatryd : Elsevierg 87:5, s. 451-461q 87:5<451-461x 0006-3223x 1873-2402
856	4	u https://liu.diva-portal.org/smash/get/diva2:1395671/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.biologicalpsychiatryjournal.com/article/S0006322319315434/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163872
856	4 8	u https://doi.org/10.1016/j.biopsych.2019.07.010

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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