Indication of Thalamo-Cortical Circuit Dysfunction in Idiopathic Normal Pressure Hydrocephalus: A Tensor Imaging Study

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Eleftheriou, AndreasLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping (author)

Indication of Thalamo-Cortical Circuit Dysfunction in Idiopathic Normal Pressure Hydrocephalus : A Tensor Imaging Study

Article/chapterEnglish2020

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2020-04-09
Nature Publishing Group,2020
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LIBRIS-ID:oai:DiVA.org:liu-165653
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-165653URI
https://doi.org/10.1038/s41598-020-63238-7DOI

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Language:English
Summary in:English

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Funding Agencies|Linkoping University
Idiopathic normal pressure hydrocephalus (iNPH) is a disorder with unclear pathophysiology. The diagnosis of iNPH is challenging due to its radiological similarity with other neurodegenerative diseases and ischemic subcortical white matter changes. By using Diffusion Tensor Imaging (DTI) we explored differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in iNPH patients (before and after a shunt surgery) and healthy individuals (HI) and we correlated the clinical results with DTI parameters. Thirteen consecutive iNPH-patients underwent a pre- and post-operative clinical work-up: 10m walk time (w10mt) steps (w10ms), TUG-time (TUGt) and steps (TUGs); for cognitive function MMSE. Nine HI were included. DTI was performed before and 3 months after surgery, HI underwent DTI once. DTI differences analyzed by manually placing 12 regions-of-interest. In patients motor and balance function improved significantly after surgery (p=0.01, p=0.025). Higher nearly significant FA values found in the patients vs HI pre-operatively in the thalamus (p=0.07) accompanied by an almost significant lower ADC (p=0.08). Significantly FA and ADC-values were found between patients and HI in FWM (p=0.02, p=0.001) and almost significant (p=0.057) pre- vs postoperatively. Postoperatively we found a trend towards the HIs FA values and a strong significant negative correlation between FA changes vs. gait results in the FWM (r=-0.7, p=0.008). Our study gives a clear indication of an ongoing pathological process in the periventricular white matter, especially in the thalamus and in the frontal white matter supporting the hypothesis of a shunt reversible thalamo-cortical circuit dysfunction in iNPH.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Blystad, IdaLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Röntgenkliniken i Linköping(Swepub:liu)idabl62 (author)
Tisell, Anders,1981-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Region Östergötland, Medicinsk strålningsfysik(Swepub:liu)andti51 (author)
Gasslander, JohanLinköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken i Norrköping(Swepub:liu)n/a (author)
Lundin, Fredrik,1968-Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)lunlu59 (author)
Linköpings universitetInstitutionen för biomedicinska och kliniska vetenskaper (creator_code:org_t)

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