Search: onr:"swepub:oai:DiVA.org:liu-165949" >
Cytokines regulate ...
Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
-
- Rao, Anna (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp Huddinge, Sweden
-
- Strauss, Otto (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp Huddinge, Sweden
-
- Kokkinou, Efthymia (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp Huddinge, Sweden
-
show more...
-
- Bruchard, Melanie (author)
- Univ Amsterdam, Netherlands
-
- Tripathi, Kumar P. (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
- Schlums, Heinrich (author)
- Karolinska Institutet
-
- Carrasco, Anna (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp Huddinge, Sweden
-
- Mazzurana, Luca (author)
- Karolinska Institutet
-
- Konya, Viktoria (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp Huddinge, Sweden
-
- Villablanca, Eduardo J. (author)
- Karolinska Institutet
-
- Bjorkstrom, Niklas K. (author)
- Karolinska Institutet
-
- Lindforss, Ulrik (author)
- Karolinska Institutet
-
- Spits, Hergen (author)
- Univ Amsterdam, Netherlands
-
- Mjösberg, Jenny (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Karolinska Inst, Sweden; Karolinska Univ Hosp Huddinge, Sweden
-
show less...
-
(creator_code:org_t)
- 2020-04-27
- 2020
- English.
-
In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 11:1
- Related links:
-
https://liu.diva-por... (primary) (Raw object)
-
show more...
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- ILCs and T helper cells have been shown to exert bi-directional regulation in mice. However, how crosstalk between ILCs and CD4(+) T cells influences immune function in humans is unknown. Here we show that human intestinal ILCs co-localize with T cells in healthy and colorectal cancer tissue and display elevated HLA-DR expression in tumor and tumor-adjacent areas. Although mostly lacking co-stimulatory molecules ex vivo, intestinal and peripheral blood (PB) ILCs acquire antigen-presenting characteristics triggered by inflammasome-associated cytokines IL-1 beta and IL-18. IL-1 beta drives the expression of HLA-DR and co-stimulatory molecules on PB ILCs in an NF-kappa B-dependent manner, priming them as efficient inducers of cytomegalovirus-specific memory CD4(+) T-cell responses. This effect is strongly inhibited by the anti-inflammatory cytokine TGF-beta. Our results suggest that circulating and tissue-resident ILCs have the intrinsic capacity to respond to the immediate cytokine milieu and regulate local CD4(+) T-cell responses, with potential implications for anti-tumor immunity and inflammation. Murine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rao, Anna
-
Strauss, Otto
-
Kokkinou, Efthym ...
-
Bruchard, Melani ...
-
Tripathi, Kumar ...
-
Schlums, Heinric ...
-
show more...
-
Carrasco, Anna
-
Mazzurana, Luca
-
Konya, Viktoria
-
Villablanca, Edu ...
-
Bjorkstrom, Nikl ...
-
Lindforss, Ulrik
-
Spits, Hergen
-
Mjösberg, Jenny
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Linköping University
-
Karolinska Institutet