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Prominent Enhanceme...
Prominent Enhancement of Cisplatin Efficacy with Optimized Methoxy Poly(ethylene glycol)-Polycaprolactone Block Copolymeric Nanoparticles
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- Yen, Ying-Tzu (author)
- Nanjing Univ, Peoples R China
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- Wang, Xinyue (author)
- Nanjing Univ, Peoples R China
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- Zhang, Huan (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Wang, Chun (author)
- Nanjing Univ, Peoples R China
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- Lin, Zitong (author)
- Nanjing Univ, Peoples R China
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- Xie, Chen (author)
- Nanjing Univ Posts and Elecommun, Ying-Tzu
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- Liu, Qin (author)
- Nanjing Univ, Peoples R China
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- Wang, Lifeng (author)
- Nanjing Univ, Peoples R China
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- Yu, Lixia (author)
- Nanjing Univ, Peoples R China
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- Xie, Li (author)
- Nanjing Univ, Peoples R China
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- Lv, Xin (author)
- Nanjing Univ, Peoples R China
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- Liu, Baorui (author)
- Nanjing Univ, Peoples R China
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- Li, Rutian (author)
- Nanjing Univ, Peoples R China
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(creator_code:org_t)
- AMER SCIENTIFIC PUBLISHERS, 2020
- 2020
- English.
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In: Journal of Biomedical Nanotechnology. - : AMER SCIENTIFIC PUBLISHERS. - 1550-7033 .- 1550-7041. ; 16:3, s. 335-343
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Chemotherapy has been one of the major standard treatments for a variety of cancers. cis-Dichlorodiamminoplatiunum(II) (cisplatin, CDDP), as one of the anticancer agents, demonstrated excellent efficacy against tumor and has been an indispensable component in chemotherapy, chemoradiation, chemo-molecular targeted therapy and chemo-immunotherapy. However, its therapeutic concentration was limited since its inevitable toxicity. Previously, we have constructed CDDP-loaded nanoparticles (NPs) with mixture of poly(ethyleneglycol)-polycaprolactone (PEG-PCL) and polycarprolactone (HO-PCL) by a facile method. The most optimal proportion of the two copolymers was selected through a series of physical, chemical, cytological and histological evaluations. In the present study, we explored the mechanisms of NPs and observed the in vivo antitumor effect after administrating CDDP-loaded PEG-PCL NPs. Positron emission tomography as well as computed tomography (PET/CT) were adopted for detecting tumoral metabolic activity. Images from fluorescence microscope revealed superior cellular uptake of CDDP-loaded NPs with rhodamine B aggregated intracellularly in cancer cells. Similar apoptotic rates between free CDDP group and CDDP-loaded NPs group was measured by flow cytometry. Tumor volumes and murine weights confirmed the superiority of CDDP-loaded NPs in therapeutic efficacy as compared with free CDDP. Blood tests showed milder side effects in CDDP-loaded nanoparticle group. PET/CT images illustrated less uptake intensity of FDG in mice received CDDP-loaded NPs than free CDDP. Our results suggest that PEG-PCL/PCL NPs could be a promising antitumor drug carrier for CDDP delivery with solid efficacy and minor side effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Nanoparticles (NPs); Block Copolymer; PEG-PCL; Cisplatin (CDDP); Drug Delivery
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Yen, Ying-Tzu
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Wang, Xinyue
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Zhang, Huan
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Wang, Chun
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Lin, Zitong
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Xie, Chen
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show more...
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Liu, Qin
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Wang, Lifeng
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Yu, Lixia
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Xie, Li
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Lv, Xin
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Liu, Baorui
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Li, Rutian
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Journal of Biome ...
- By the university
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Linköping University