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Cerebrospinal fluid...
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia
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- Llorens, Franc (author)
- Univ Med Ctr Gottingen, Germany; Minist Hlth, Spain; Bellvitge Biomed Res Inst IDIBELL, Spain,University Medical Center Göttingen,Carlos III Health Institute,Bellvitge University Hospital-IDIBELL
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- Hermann, Peter (author)
- Univ Med Ctr Gottingen, Germany,University Medical Center Göttingen
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- Villar-Pique, Anna (author)
- Univ Med Ctr Gottingen, Germany,University Medical Center Göttingen
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- Diaz-Lucena, Daniela (author)
- Minist Hlth, Spain,Carlos III Health Institute
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- Nägga, Katarina (author)
- Linköping University,Lund University,Lunds universitet,Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Santana, Isabel (author)
- Univ Coimbra, Portugal; Univ Coimbra, Portugal,University of Coimbra
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- Schmitz, Matthias (author)
- Univ Med Ctr Gottingen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany,University Medical Center Göttingen,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Schmidt, Christian (author)
- Univ Med Ctr Gottingen, Germany; Klinikum Kassel, Germany,University Medical Center Göttingen
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- Varges, Daniela (author)
- Univ Med Ctr Gottingen, Germany,University Medical Center Göttingen
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- Goebel, Stefan (author)
- Univ Med Ctr Gottingen, Germany,University Medical Center Göttingen
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- Dumurgier, Julien (author)
- Univ Paris Diderot, France; Univ Paris Diderot, France,Paris Diderot University,Lariboisière Hospital
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Paquet, Claire (author)
- Univ Paris Diderot, France; Univ Paris Diderot, France,Lariboisière Hospital,Paris Diderot University
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- Baldeiras, Ines (author)
- Univ Coimbra, Portugal; Univ Coimbra, Portugal,University Hospital of Coimbra
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- Ferrer, Isidro (author)
- Minist Hlth, Spain; Bellvitge Biomed Res Inst IDIBELL, Spain; Univ Barcelona, Spain; Univ Barcelona, Spain,University of Barcelona,Carlos III Health Institute,Bellvitge University Hospital-IDIBELL
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- Zerr, Inga (author)
- Univ Med Ctr Gottingen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany,University Medical Center Göttingen,German Center for Neurodegenerative Diseases (DZNE), Bonn
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(creator_code:org_t)
- 2020-01-30
- 2020
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 11:1
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n=472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimers disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias. Diagnosis of vascular dementia is hampered by the lack of biochemical markers for this disease. Here, the authors show that vascular dementia is associated with increased lipocalin-2 in cerebrospinal fluid, compared to controls and patients with other forms of dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Llorens, Franc
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Hermann, Peter
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Villar-Pique, An ...
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Diaz-Lucena, Dan ...
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Nägga, Katarina
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Hansson, Oskar
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show more...
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Santana, Isabel
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Schmitz, Matthia ...
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Schmidt, Christi ...
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Varges, Daniela
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Goebel, Stefan
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Dumurgier, Julie ...
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Zetterberg, Henr ...
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Blennow, Kaj
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Paquet, Claire
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Baldeiras, Ines
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Ferrer, Isidro
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Zerr, Inga
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Communica ...
- By the university
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Linköping University
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Lund University
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University of Gothenburg