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Amyotrophic lateral sclerosis : Evidence for intact hepatocyte growth factor/MET signalling axis
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- Kern, M A (author)
- Department of Neuroscience, Neurobiology, Uppsala University, Box 587, S-75123, Uppsala, Sweden; Institute of Pathology, University of Cologne, Joseph-Stelzmann-Str. 9, D-50931, Cologne, Germany
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- Friese, M (author)
- Institute of Pathology, University of Cologne, Joseph-Stelzmann-Str. 9, D-50931, Cologne, Germany
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- Grundstrom, E (author)
- Department of Neuroscience, Neurology, Uppsala University, UAS, S-75185, Uppsala, Sweden
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- Department of Neuroscience, Neurobiology, Uppsala University, Box 587, S-75123, Uppsala, Sweden; Institute of Pathology, University of Cologne, Joseph-Stelzmann-Str 9, D-50931, Cologne, Germany Institute of Pathology, University of Cologne, Joseph-Stelzmann-Str. 9, D-50931, Cologne, Germany (creator_code:org_t)
- W B SAUNDERS CO, 2001
- 2001
- English.
- In: Cytokine. - : W B SAUNDERS CO. - 1043-4666 .- 1096-0023. ; 15:6, s. 315-319
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Hepatocyte growth factor (HGF) is a secreted cytokine which is expressed in the central nervous system (CNS) together with its specific receptor MET. Since HGF exerts strong neurotrophic activity including motoneurons, we have further analysed whether the HGF/MET axis is defective in patients with amyotrophic lateral sclerosis (ALS). Intrathecal HGF-secretion was measured in cerebrospinal fluid (CSF) from patients with amyotrophic lateral sclerosis and in controls without neurological diseases using a specific sandwich immunoassay (ELISA). MET-expression was analysed by immunohistology in spinal cord cross-sections of ALS patients and unaffected controls. The HGF concentrations in CSF were moderately but significantly increased in ALS patients compared to healthy controls (580 pg/ml vs 348 pg/ml). MET-protein was detectable in spinal cord motoneurons of patients with ALS as well as unaffected controls. The data demonstrate that ALS does not show a lack of the trophic signalling axis, HGF/MET, suggesting that the signalling system itself is not affected. The moderate increase in HGF-secretion may represent a compensatory effect.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- ALS
- cerebrospinal fluid
- Hepatocyte growth factor
- enzyme-linked immunosorbent assay
- motoneuron
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- ref (subject category)
- art (subject category)
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- Kern, M A
- Friese, M
- Grundstrom, E
- Korhonen, L
- Wallin, A
- Aquilonius, S M
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- Askmark, H
- Schirmacher, P
- Lindholm, D
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
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- Cytokine
- By the university
- Linköping University
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