Search: onr:"swepub:oai:DiVA.org:liu-168081" > Biomarkers of liver...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07513naa a2200553 4500 | |
001 | oai:DiVA.org:liu-168081 | |
003 | SwePub | |
008 | 200814s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1680812 URI |
024 | 7 | a https://doi.org/10.1080/00365521.2020.17865992 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Forsgren, Mikael F,d 1983-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik4 aut0 (Swepub:liu)mikfo34 |
245 | 1 0 | a Biomarkers of liver fibrosis :b prospective comparison of multimodal magnetic resonance, serum algorithms and transient elastography. |
264 | c 2020-07-20 | |
264 | 1 | b Taylor & Francis,c 2020 |
338 | a electronic2 rdacarrier | |
500 | a Funding agencies: Swedish Research Council (VR/MH, #2007- 2884 as well as VR/NT #2014-6157 both to P. L.), the Medical Research council of Southeast Sweden (FORSS #12621 to P. L.), Vinnova (#2013- 01314 to P. L.), the Linköping University, the Linköping University Hospital Research Foundations, and Region Ostergötland. | |
520 | a BACKGROUND AND AIMS: Accurate biomarkers for quantifying liver fibrosis are important for clinical practice and trial end-points. We compared the diagnostic performance of magnetic resonance imaging (MRI), including gadoxetate-enhanced MRI and 31P-MR spectroscopy, with fibrosis stage and serum fibrosis algorithms in a clinical setting. Also, in a subset of patients, MR- and transient elastography (MRE and TE) was evaluated when available.METHODS: Patients were recruited prospectively if they were scheduled to undergo liver biopsy on a clinical indication due to elevated liver enzyme levels without decompensated cirrhosis. Within a month of the clinical work-up, an MR-examination and liver needle biopsy were performed on the same day. Based on late-phase gadoxetate-enhanced MRI, a mathematical model calculated hepatobiliary function (relating to OATP1 and MRP2). The hepatocyte gadoxetate uptake rate (KHep) and the normalised liver-to-spleen contrast ratio (LSC_N10) were also calculated. Nine serum fibrosis algorithms were investigated (GUCI, King's Score, APRI, FIB-4, Lok-Index, NIKEI, NASH-CRN regression score, Forns' score, and NAFLD-fibrosis score).RESULTS: The diagnostic performance (AUROC) for identification of significant fibrosis (F2-4) was 0.78, 0.80, 0.69, and 0.78 for MRE, TE, LSC_N10, and GUCI, respectively. For the identification of advanced fibrosis (F3-4), the AUROCs were 0.93, 0.84, 0.81, and 0.82 respectively.CONCLUSION: MRE and TE were superior for non-invasive identification of significant fibrosis. Serum fibrosis algorithms developed for specific liver diseases are applicable in this cohort of diverse liver diseases aetiologies. Gadoxetate-MRI was sufficiently sensitive to detect the low function losses associated with fibrosis. None was able to efficiently distinguish between stages within the low fibrosis stages.Lay summaryExcessive accumulation of scar tissue, fibrosis, in the liver is an important aspect in chronic liver disease. To replace the invasive needle biopsy, we have explored non-invasive methods to assess liver fibrosis. In our study we found that elastographic methods, which assess the mechanical properties of the liver, are superior in assessing fibrosis in a clinical setting. Of interest from a clinical trial point-of-view, none of the tested methods was sufficiently accurate to distinguish between adjacent moderate fibrosis stages. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
653 | a 31P-MR spectroscopy | |
653 | a Elastography | |
653 | a Gadoxetate-enhanced MRI | |
653 | a MRE | |
653 | a liver fibrosis | |
653 | a serum fibrosis algorithms | |
700 | 1 | a Nasr, Patrik,d 1987-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)patna19 |
700 | 1 | a Karlsson, Markus,d 1990-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik4 aut0 (Swepub:liu)marka46 |
700 | 1 | a Dahlström, Nils,d 1969-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping4 aut0 (Swepub:liu)nilda87 |
700 | 1 | a Norén, Bengt,d 1955-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping4 aut0 (Swepub:liu)benno19 |
700 | 1 | a Ignatova, Simone,d 1971-u Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi4 aut0 (Swepub:liu)simig66 |
700 | 1 | a Sinkus, Ralphu King's College London, United Kingdom4 aut |
700 | 1 | a Cedersund, Gunnar,d 1978-u Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten4 aut0 (Swepub:liu)gunce57 |
700 | 1 | a Dahlqvist Leinhard, Olof,d 1978-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik4 aut0 (Swepub:liu)oloda24 |
700 | 1 | a Ekstedt, Mattias,d 1976-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)matek92 |
700 | 1 | a Kechagias, Stergios,d 1969-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)steke00 |
700 | 1 | a Lundberg, Peter,d 1958-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik4 aut0 (Swepub:liu)petlu11 |
710 | 2 | a Linköpings universitetb Avdelningen för diagnostik och specialistmedicin4 org |
773 | 0 | t Scandinavian Journal of Gastroenterologyd : Taylor & Francisg 55:7, s. 848-859q 55:7<848-859x 0036-5521x 1502-7708 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1458189/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.tandfonline.com/doi/pdf/10.1080/00365521.2020.1786599?needAccess=true |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168081 |
856 | 4 8 | u https://doi.org/10.1080/00365521.2020.1786599 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view