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  • Parkula, VitaliyUniv Modena & Reggio Emilia, Italy; Scriba Nanotecnol Srl, Italy (author)

Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-06-02
  • AMER CHEMICAL SOC,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-168319
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168319URI
  • https://doi.org/10.1021/acs.analchem.0c01655DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|European CommissionEuropean Commission Joint Research Centre [GA-642196, GA-813863]; EuroNanoMed III project "AMI"; Life Science Department of the University of Modena and Reggio Emilia; Agence Nationale de la Recherche through the Labex project CSC within the Investissement dAvenir programFrench National Research Agency (ANR) [ANR-10-LABX-0026 CSC, ANR-10-120 IDEX-000202]; European UnionEuropean Union (EU) [732678]
  • Electrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to ultimately harness selectivity in the detection process. We report a novel lab-on-a-chip device integrating a multigate electrolyte gated organic field-effect transistor (EGOFET) with a 6.5 mu L microfluidics set up capable to provide an assessment of both the response reproducibility, by enabling measurement in triplicate, and of the device selectivity through the presence of an internal reference electrode. As proof-of-concept, we demonstrate the efficient operation of our pentacene based EGOFET sensing platform through the quantification of tumor necrosis factor alpha with a detection limit as low as 3 pM. Sensing of inflammatory cytokines, which also include TNF alpha, is of the outmost importance for monitoring a large number of diseases. The multiplexable organic electronic lab-on-chip provides a statistically solid, reliable, and selective response on microliters sample volumes on the minutes time scale, thus matching the relevant key-performance indicators required in point-of-care diagnostics.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Berto, MarcelloUniv Modena & Reggio Emilia, Italy (author)
  • Diacci, ChiaraLinköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Univ Modena & Reggio Emilia, Italy(Swepub:liu)chidi30 (author)
  • Patrahau, BiancaUniv Modena & Reggio Emilia, Italy; Univ Strasbourg, France (author)
  • Di Lauro, MicheleUniv Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy (author)
  • Kovtun, AlessandroCNR, Italy (author)
  • Liscio, AndreaCNR, Italy (author)
  • Sensi, MatteoUniv Modena & Reggio Emilia, Italy (author)
  • Samori, PaoloUniv Strasbourg, France (author)
  • Greco, PierpaoloScriba Nanotecnol Srl, Italy (author)
  • Bortolotti, Carlo A.Univ Modena & Reggio Emilia, Italy (author)
  • Biscarini, FabioUniv Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy (author)
  • Univ Modena & Reggio Emilia, Italy; Scriba Nanotecnol Srl, ItalyUniv Modena & Reggio Emilia, Italy (creator_code:org_t)

Related titles

  • In:Analytical Chemistry: AMER CHEMICAL SOC92:13, s. 9330-93370003-27001520-6882

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