Sökning: onr:"swepub:oai:DiVA.org:liu-168841" >
Rotavirus A sheddin...
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Cantelli, Carina PachecoFiocruz MS, Brazil; Fiocruz MS, Brazil
(författare)
Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-04-24
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NATURE PUBLISHING GROUP,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-168841
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168841URI
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https://doi.org/10.1038/s41598-020-64025-0DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144387015URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Oswaldo Cruz Institute/Fiocruz/PAEF; "The Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro" (FAPERJ)Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) [E-26/202.968/2015]; "The National Council for Scientific and Technological Development" (CNPq)National Council for Scientific and Technological Development (CNPq) [424376/2016-4]; "Coordination for the Improvement of Higher Education Personnel - CAPES"- PrInt-Fiocruz-CAPESCAPES; PROGRAMA DE PROFESSOR VISITANTE NO EXTERIOR [88881.337140/2019-01]
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Recent studies have investigated whether the human histo-blood group antigen (HBGAs) could affect the effectiveness of the oral rotavirus vaccines, suggesting secretor positive individuals develop a more robust response. We investigated the Rotavirus A (RVA) shedding in association with the host susceptibility profile in children from a birth community-cohort in Rio de Janeiro, Brazil, from 2014 to 2018. A total of 132 children were followed-up between 0 to 11-month-old, stool samples were collected before/after the 1(st)/2(nd) RV1 vaccination doses and saliva samples were collected during the study. RVA shedding was screened by RT-qPCR and G/P genotypes determined by multiplex RT-PCR and/or Sanger nucleotide sequencing. The sequencing indicated an F167L amino acid change in the RV1 VP8* P[8] in 20.5% of shedding follow-ups and these mutant subpopulations were quantified by pyrosequencing. The HBGA/secretor status was determined and 80.3% of the children were secretors. Twenty-one FUT2 gene SNPs were identified and two new mutations were observed. The mutant F167L RV1 VP8* P[8] was detected significantly more in Le (a+b+) secretors (90.5%) compared to non-secretors and even to secretors Le (a-b+) (9.5%). The study highlights the probable association between RV1 shedding and HBGAs as a marker for evaluating vaccine strain host susceptibility.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Velloso, Alvaro JorgeFiocruz MS, Brazil
(författare)
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Santos de Assis, Rosane MariaFiocruz MS, Brazil
(författare)
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Barros, Jose JuniorFiocruz MS, Brazil
(författare)
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do Amaral Mello, Francisco CampelloFiocruz MS, Brazil
(författare)
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da Cunha, Denise CotrimFiocruz MS, Brazil
(författare)
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Brasil, PatriciaFiocruz MS, Brazil
(författare)
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Nordgren, JohanLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)johno12
(författare)
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Svensson, LennartKarolinska Institutet,Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)lensv66
(författare)
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Miagostovich, Marize PereiraFiocruz MS, Brazil
(författare)
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Gagliardi Leite, Jose PauloFiocruz MS, Brazil
(författare)
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de Moraes, Marcia Terezinha BaroniFiocruz MS, Brazil
(författare)
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Fiocruz MS, Brazil; Fiocruz MS, BrazilFiocruz MS, Brazil
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: NATURE PUBLISHING GROUP10:12045-2322
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Cantelli, Carina ...
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Velloso, Alvaro ...
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Santos de Assis, ...
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Barros, Jose Jun ...
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do Amaral Mello, ...
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da Cunha, Denise ...
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visa fler...
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Brasil, Patricia
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Nordgren, Johan
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Svensson, Lennar ...
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Miagostovich, Ma ...
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Gagliardi Leite, ...
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de Moraes, Marci ...
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visa färre...
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Linköpings universitet
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