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Utility of Tear Osm...
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
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- Tashbayev, Bezhod (author)
- Univ Oslo, Norway
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- Utheim, Tor Paaske (author)
- Norwegian Dry Eye Clin, Norway; Oslo Univ Hosp, Norway; Oslo Univ Hosp, Norway; Univ Oslo, Norway; Vestre Viken Hosp Trust, Norway; Sorlandet Hosp Arendal, Norway; Univ South Eastern Norway, Norway
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- Utheim, Oygunn Aass (author)
- Norwegian Dry Eye Clin, Norway
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- Raeder, Sten (author)
- Norwegian Dry Eye Clin, Norway
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- Jensen, Janicke Liaaen (author)
- Univ Oslo, Norway
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- Yazdani, Mazyar (author)
- Norwegian Dry Eye Clin, Norway; Oslo Univ Hosp, Norway
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- Lagali, Neil (author)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US,Sorlandet Hosp Arendal, Norway
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- Vitelli, Valeria (author)
- Univ Oslo, Norway
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- Dartt, Darlene A. (author)
- Harvard Med Sch, MA 02115 USA
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- Chen, Xiangjun (author)
- Univ Oslo, Norway; Vestre Viken Hosp Trust, Norway; Sorlandet Hosp Arendal, Norway; Univ South Eastern Norway, Norway
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(creator_code:org_t)
- 2020-03-26
- 2020
- English.
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In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
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Abstract
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- The prevalence of dry eye disease is high worldwide and poses a great burden on patients daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is believed to be the disease marker and thus measuring it provides useful information. In this study we investigated utility of tear osmolarity measured with TearLab osmometer, along with other diagnostic tests (Ocular Surface Disease Index questionnaire, Tear film break-up time, Ocular Protection Index, Ocular Surface Staining, Schirmer I test, Meibomian gland functionality in 757 patients (1514 eyes) with dry eye disease and 29 healthy controls (58 eyes). Statistical differences between the patient group and the control group were observed for all the tests apart from tear osmolarity, regardless of cut-off value (>308 mOsm/L, >316 mOsm/L, and inter-eye difference >8 mOsm/L). Moreover, in the receiver operating characteristics curve analyses tear osmolarity measurement could not discriminate dry eye disease pathological scores. Therefore, our study suggests that tear osmolarity measured with TearLab osmometer cannot be used as a key indicator of DED.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- ref (subject category)
- art (subject category)
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Tashbayev, Bezho ...
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Utheim, Tor Paas ...
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Utheim, Oygunn A ...
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Raeder, Sten
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Jensen, Janicke ...
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Yazdani, Mazyar
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show more...
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Lagali, Neil
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Vitelli, Valeria
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Dartt, Darlene A ...
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Chen, Xiangjun
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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Scientific Repor ...
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Linköping University