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- Shen, JieAnhui Univ, Peoples R China (author)
Real-time monitoring of lipid droplets growth via the fusion with fluorescent dye-labeled adiposomes
- Article/chapterEnglish2020
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- ELSEVIER SCI LTD,2020
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- LIBRIS-ID:oai:DiVA.org:liu-169953
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169953URI
- https://doi.org/10.1016/j.dyepig.2020.108653DOI
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- Language:English
- Summary in:English
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- Funding Agencies|National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21775001, 21705001, 21974001]; Natural Science Foundation of Anhui ProvinceNatural Science Foundation of Anhui Province [1808085MB32]; STINT Joint ChinaSweden Mobility Project Program [CH2017-7243]
- Investigating lipid droplets (LDs) behaviours is essential to deeply understand the physiology of LDs, such as their growths, movements, fusion/division, and autophagy. Among these behaviours, the growth of LDs is one of the most difficult to track due to the very subtle morphology evolution in a short time window. The major obstacle is that conventional LDs-specific dyes with low photostability cannot indicate the LDs size change. To address this issue, we synthesize a hydrophobic and photostable fluorescent dye (TPA-AD) and load it into the neutral lipid micelles (as artificial adiposomes). The highly hydrophobic TPA-AD enables the specific accumulation into intracellular LDs and the ready loading artificial adiposomes. When the intracellular LDs take TPA-AD-labeled adiposomes, by fusion, the sizes of LDs gradually grow, and LDs are simultaneously lighted up by the fluorescence of TPA-AD. Importantly, the high photostability of TPA-AD ensures the enhanced fluorescence signals. The finding here will further strengthen the understanding of LDs dynamics and fat metabolism.
Subject headings and genre
- NATURVETENSKAP Fysik Atom- och molekylfysik och optik hsv//swe
- NATURAL SCIENCES Physical Sciences Atom and Molecular Physics and Optics hsv//eng
- Hydrophobic fluorescent dye; Lipid droplets growth; Adiposomes
Added entries (persons, corporate bodies, meetings, titles ...)
- Feng, WenxunAnhui Univ, Peoples R China (author)
- Tian, XiaoheAnhui Univ, Peoples R China (author)
- Liu, ZhengjieAnhui Univ, Peoples R China (author)
- Han, GuangmeiAnhui Univ, Peoples R China (author)
- Zhang, RuilongAnhui Univ, Peoples R China (author)
- Hu, Zhang-JunLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)zhahu14 (author)
- Zhang, ZhongpingAnhui Univ, Peoples R China (author)
- Anhui Univ, Peoples R ChinaMolekylär ytfysik och nanovetenskap (creator_code:org_t)
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- In:Dyes and pigments: ELSEVIER SCI LTD1820143-72081873-3743
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