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Cognitive markers o...
Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause
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- Gervais, Nicole J. (author)
- Univ Toronto, Canada
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- Au, April (author)
- Univ Toronto, Canada
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- Almey, Anne (author)
- Univ Toronto, Canada
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- Duchesne, Annie (author)
- Univ Northern British Columbia, Canada
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- Gravelsins, Laura (author)
- Univ Toronto, Canada
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- Brown, Alana (author)
- Univ Toronto, Canada
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- Reuben, Rebekah (author)
- Univ Toronto, Canada
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- Baker-Sullivan, Elizabeth (author)
- Univ Toronto, Canada
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- Schwartz, Deborah H. (author)
- Univ Toronto, Canada
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- Evans, Kelly (author)
- Univ Toronto, Canada
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- Bernardini, Marcus Q. (author)
- Princess Margaret Canc Ctr, Canada
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- Eisen, Andrea (author)
- Sunnybrook Hlth Sci Ctr, Canada
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- Meschino, Wendy S. (author)
- North York Gen Hosp, Canada
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- Foulkes, William D. (author)
- Jewish Gen Hosp, Canada; McGill Univ, Canada
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- Hampson, Elizabeth (author)
- Western Univ, Canada
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- Einstein, Gillian (author)
- Linköpings universitet,Tema Genus,Filosofiska fakulteten,Univ Toronto, Canada; Rotman Res Inst, Canada
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2020
- 2020
- English.
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In: Neurobiology of Aging. - : ELSEVIER SCIENCE INC. - 0197-4580 .- 1558-1497. ; 94
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Oophorectomy prior to menopause is associated with late-life dementia. Memory decline may start within 6 months after oophorectomy in middle-aged women, suggested by lower verbal and working memory performance. Unknown is whether such changes persist beyond 6 months, and whether they are reversed by estradiol. Short-term benefits of estradiol on verbal memory following oophorectomy were observed in one study, but longer term effects remain unknown. In the present study, middle-aged BRCA1/2 mutation carriers with early oophorectomy at least 1 year prior to study onset were tested on verbal and working memory with results stratified by (1) current estradiol use (n = 22) or (2) no history of estradiol use (n = 24), and compared to age-matched premenopausal controls (n = 25). Both memory abilities were adversely affected by oophorectomy, but only working memory was maintained by estradiol. Estrogen metabolite levels correlated with working memory, suggesting a role for estradiol in preserving this ability. Memory decline appears to persist after early oophorectomy, particularly for women who do not take estradiol. (C) 2020 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Estradiol deprivation; Dementia risk; Estradiol; Working memory; Verbal memory; Oophorectomy; Surgical menopause
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gervais, Nicole ...
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Au, April
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Almey, Anne
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Duchesne, Annie
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Gravelsins, Laur ...
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Brown, Alana
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Reuben, Rebekah
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Baker-Sullivan, ...
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Schwartz, Debora ...
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Evans, Kelly
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Bernardini, Marc ...
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Eisen, Andrea
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Meschino, Wendy ...
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Foulkes, William ...
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Hampson, Elizabe ...
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Einstein, Gillia ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Neurobiology of ...
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Linköping University