Sprayed cultured autologous keratinocytes in the treatment of severe burns: a retrospective matched cohort study.

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Sprayed cultured autologous keratinocytes in the treatment of severe burns : a retrospective matched cohort study.

Karlsson, Matilda, 1981- (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US

Steinvall, Ingrid, 1959- (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US

Olofsson, Pia, 1962- (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US

Thorfinn, Johan, 1970- (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US

Sjöberg, Folke, 1956- (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US

Åstrand, Liselott (author): Sharjah Institute for Medical Research, University of Sharjah, UAE

Fayiz, Safa (author): Sharjah Institute for Medical Research, University of Sharjah, UAE

Khalaf, Ahmed (author): Sharjah Institute for Medical Research, University of Sharjah, UAE

Divyasree, Parambath (author): Sharjah Institute for Medical Research, University of Sharjah, UAE

El-Serafi, Ahmed Taher, 1977- (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US,Sharjah Institute for Medical Research, University of Sharjah, UAE; Suez Canal University, Ismailia, Egypt

Elmasry, Moustafa, 1981- (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US

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Palermo, Italy : Mediterranean Council for Burns and Fire Disasters, 2020
2020
English.
In: Annals of burns and fire disasters. - Palermo, Italy : Mediterranean Council for Burns and Fire Disasters. - 1592-9558. ; 33:2, s. 134-142

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

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The standard treatment of burns is early excision followed by autologous skin grafting. The closure of extensive deep burns poses a considerable challenge. Cultured autologous keratinocytes have been used since 1981 in an effort to improve healing. However, the time required to culture the cells and the lack of a dermal component limit the expectations of outcome. Our aim was to compare the duration of hospital stay between patients who were treated with autologous skin grafts and cultured autologous keratinocytes and those who were treated with autologous skin grafting without cultured autologous keratinocytes. In this retrospective study all patients treated with cultured autologous keratinocytes between 2012 and 2015 were matched by size and depth of burn with patients not treated with cultured autologous keratinocytes. Multivariable regression was used to analyse associations between duration of hospital stay and treatment adjusted for age, mortality, size and depth of the burn. Then, we investigated the possibility of differentiation of human bone marrow stem cell line to keratinocyte- like cells as a future direction. The regression analysis showed a coefficient of 17.36 (95% CI -17.69 to 52.40), p= 0.32, for hospital stay in the treatment group, compared with the matched group. Our results showed no difference in the duration of hospital stay between the two treatments. Autologous stem cells should be considered as a future modality of burn management, although further studies are needed.

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By the author/editor: Karlsson, Matild ...; Steinvall, Ingri ...; Olofsson, Pia, 1 ...; Thorfinn, Johan, ...; Sjöberg, Folke, ...; Åstrand, Liselot ...; show more...; Fayiz, Safa; Khalaf, Ahmed; Divyasree, Param ...; El-Serafi, Ahmed ...; Elmasry, Moustaf ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

Articles in the publication: Annals of burns ...

By the university: Linköping University

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Sprayed cultured autologous keratinocytes in the treatment of severe burns : a retrospective matched cohort study.

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