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Sprayed cultured au...
Sprayed cultured autologous keratinocytes in the treatment of severe burns : a retrospective matched cohort study.
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- Karlsson, Matilda, 1981- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Steinvall, Ingrid, 1959- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Olofsson, Pia, 1962- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Thorfinn, Johan, 1970- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Sjöberg, Folke, 1956- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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- Åstrand, Liselott (author)
- Sharjah Institute for Medical Research, University of Sharjah, UAE
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- Fayiz, Safa (author)
- Sharjah Institute for Medical Research, University of Sharjah, UAE
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- Khalaf, Ahmed (author)
- Sharjah Institute for Medical Research, University of Sharjah, UAE
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- Divyasree, Parambath (author)
- Sharjah Institute for Medical Research, University of Sharjah, UAE
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- El-Serafi, Ahmed Taher, 1977- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US,Sharjah Institute for Medical Research, University of Sharjah, UAE; Suez Canal University, Ismailia, Egypt
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- Elmasry, Moustafa, 1981- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
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(creator_code:org_t)
- Palermo, Italy : Mediterranean Council for Burns and Fire Disasters, 2020
- 2020
- English.
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In: Annals of burns and fire disasters. - Palermo, Italy : Mediterranean Council for Burns and Fire Disasters. - 1592-9558. ; 33:2, s. 134-142
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The standard treatment of burns is early excision followed by autologous skin grafting. The closure of extensive deep burns poses a considerable challenge. Cultured autologous keratinocytes have been used since 1981 in an effort to improve healing. However, the time required to culture the cells and the lack of a dermal component limit the expectations of outcome. Our aim was to compare the duration of hospital stay between patients who were treated with autologous skin grafts and cultured autologous keratinocytes and those who were treated with autologous skin grafting without cultured autologous keratinocytes. In this retrospective study all patients treated with cultured autologous keratinocytes between 2012 and 2015 were matched by size and depth of burn with patients not treated with cultured autologous keratinocytes. Multivariable regression was used to analyse associations between duration of hospital stay and treatment adjusted for age, mortality, size and depth of the burn. Then, we investigated the possibility of differentiation of human bone marrow stem cell line to keratinocyte- like cells as a future direction. The regression analysis showed a coefficient of 17.36 (95% CI -17.69 to 52.40), p= 0.32, for hospital stay in the treatment group, compared with the matched group. Our results showed no difference in the duration of hospital stay between the two treatments. Autologous stem cells should be considered as a future modality of burn management, although further studies are needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- burn
- duration of hospital stay
- outcome
- sprayed cultured autologous keratinocytes
- stem cells
Publication and Content Type
- ref (subject category)
- art (subject category)
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Karlsson, Matild ...
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Steinvall, Ingri ...
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Olofsson, Pia, 1 ...
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Thorfinn, Johan, ...
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Sjöberg, Folke, ...
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Åstrand, Liselot ...
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Fayiz, Safa
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Khalaf, Ahmed
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Divyasree, Param ...
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El-Serafi, Ahmed ...
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Elmasry, Moustaf ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Annals of burns ...
- By the university
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Linköping University