Actinic Keratosis Diagnosis and Increased Risk of Developing Skin Cancer: A 10-year Cohort Study of 17,651 Patients in Sweden

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Guorgis, GhassanLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten (author)

Actinic Keratosis Diagnosis and Increased Risk of Developing Skin Cancer : A 10-year Cohort Study of 17,651 Patients in Sweden

Article/chapterEnglish2020

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2020
Uppsala, Sweden :Society for the Publication of Acta Dermato - Venereologica,2020
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LIBRIS-ID:oai:DiVA.org:liu-170592
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170592URI
https://doi.org/10.2340/00015555-3486DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Actinic keratosis is the most common actinic lesion in fair-skinned populations. It is accepted as an indicator of actinic skin damage and as an occasional precursor of squamous cell carcinoma. The aim of this study was to investigate, in a cohort of patients with a diagnosis of actinic keratosis, the relative risk of developing skin cancer during a follow-up period of 10 years. This registry-based cohort study compared a cohort of 2,893 individuals in south-eastern Sweden, who were diagnosed with actinic keratosis during the period 2000 to 2004, with a matched-control cohort of 14,668 individuals without actinic keratosis during the same inclusion period. The subjects were followed for 10 years to identify skin cancer development in both cohorts. Hazard ratios with 95% confidence intervals (95% CI) were used as risk measures. Individuals in the actinic keratosis cohort had a markedly higher risk for all skin cancer forms compared with the control cohort (hazard ratio (HR) 5.1, 95% CI 4.7-5.6). The relative risk was highest for developing squamous cell carcinoma (SCC) (HR 7.7, 95% CI 6.7-8.8) and somewhat lower for basal cell carcinoma (BCC) (HR 4.4, 95% CI 4.1-5.0) and malignant melanoma (MM) (HR 2.7 (2.1-3.6). Patients with a diagnosis of actinic keratosis were found to be at increased risk of developing SCC, BCC and MM in the 10 years following diagnosis of actinic keratosis. In conclusion, a diagnosis of actinic keratosis, even in the absence of documentation of other features of chronic sun exposure, is a marker of increased risk of skin cancer, which should be addressed with individually directed preventive advice.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
actinic keratosis
basal cell carcinoma
cohort study
melanoma
squamous cell carcinoma
skin cancer

Added entries (persons, corporate bodies, meetings, titles ...)

Anderson, Chris D.,1949-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland(Swepub:liu)chran78 (author)
Lyth, Johan,1980-Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten,Region Östergötland, Forskningsstrategiska enheten(Swepub:liu)johly06 (author)
Falk, Magnus,1968-Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Vårdcentralen Kärna(Swepub:liu)magfa32 (author)
Linköpings universitetAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)

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In:Acta Dermato-VenereologicaUppsala, Sweden : Society for the Publication of Acta Dermato - Venereologica100:80001-55551651-2057

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