Search: onr:"swepub:oai:DiVA.org:liu-171353" >
Visualization of hu...
Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo
-
- He, Xingkang (author)
- Karolinska Inst, Sweden; Zhejiang Univ, Peoples R China
-
- Yin, Xin (author)
- Karolinska Inst, Sweden; Zhejiang Univ, Peoples R China,Karolinska Inst, Sweden; Sun Yat Sen Univ, Peoples R China
-
- Wu, Jing (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
show more...
-
- Wickstrom, Stina L. (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Duo, Yanhong (author)
- Karolinska Inst, Sweden
-
- Du, Qiqiao (author)
- Karolinska Inst, Sweden; Sun Yat Sen Univ, Peoples R China
-
- Qin, Shuhang (author)
- Karolinska Inst, Sweden; Sun Yat Sen Univ, Peoples R China
-
- Yao, Shuzhong (author)
- Sun Yat Sen Univ, Peoples R China
-
- Jing, Xu (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Hosaka, Kayoko (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Wu, Jieyu (author)
- Karolinska Inst, Sweden
-
- Jensen, Lasse (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi
-
- Lundqvist, Andreas (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Salter, Alexander I (author)
- Fred Hutchinson Canc Res Ctr, WA 98109 USA
-
- Brautigam, Lars (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Tao, Wei (author)
- Harvard Med Sch, MA 02115 USA; Harvard Med Sch, MA 02115 USA
-
- Chen, Yuguo (author)
- Shandong Univ, Peoples R China
-
- Kiessling, Rolf (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Cao, Yihai (author)
- Karolinska Institutet,Karolinska Inst, Sweden
-
show less...
-
(creator_code:org_t)
- 2020-08-28
- 2020
- English.
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 117:37, s. 22910-22919
- Related links:
-
https://www.pnas.org...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Lymphocyte-based immunotherapy has emerged as a break-through in cancer therapy for both hematologic and solid malignancies. In a subpopulation of cancer patients, this powerful therapeutic modality converts malignancy to clinically manageable disease. However, the T cell- and chimeric antigen receptor T (CAR-T) cell-mediated antimetastatic activity, especially their impacts on microscopic metastatic lesions, has not yet been investigated. Here we report a living zebrafish model that allows us to visualize the metastatic cancer cell killing effect by tumor- infiltrating lymphocytes (TILs) and CAR-T cells in vivo at the single-cell level. In a freshly isolated primary human melanoma, specific TILs effectively eliminated metastatic cancer cells in the living body. This potent metastasis-eradicating effect was validated using a human lymphoma model with CAR-T cells. Furthermore, cancer-associated fibroblasts protected metastatic cancer cells from T cell-mediated killing. Our data provide an in vivo platform to validate antimetastatic effects by human T cell-mediated immunotherapy. This unique technology may serve as a precision medicine platform for assessing anticancer effects of cellular immunotherapy in vivo before administration to human cancer patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- cancer; metastasis; lymphocyte; zebrafish; cancer therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
He, Xingkang
-
Yin, Xin
-
Wu, Jing
-
Wickstrom, Stina ...
-
Duo, Yanhong
-
Du, Qiqiao
-
show more...
-
Qin, Shuhang
-
Yao, Shuzhong
-
Jing, Xu
-
Hosaka, Kayoko
-
Wu, Jieyu
-
Jensen, Lasse
-
Lundqvist, Andre ...
-
Salter, Alexande ...
-
Brautigam, Lars
-
Tao, Wei
-
Chen, Yuguo
-
Kiessling, Rolf
-
Cao, Yihai
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Proceedings of t ...
- By the university
-
Linköping University
-
Karolinska Institutet