Search: onr:"swepub:oai:DiVA.org:liu-17143" >
The Ile646Val (2073...
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Wang, Mo-JinSichuan University
(author)
The Ile646Val (2073A > G) Polymorphism in the Kinase-Binding Domain of A-Kinase Anchoring Protein 10 and the Risk of Colorectal Cancer
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-02-11
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S. Karger AG,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-17143
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17143URI
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https://doi.org/10.1159/000201572DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objective: The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC. Methods: Applying TaqMan allelic discrimination, we investigated AKAP10 Ile646Val (2073A>G) polymorphism in 288 Chinese CRC patients and 281 healthy controls. Results: Logistic regression analysis revealed a significant association of AKAP10 Ile646Val (2073A>G) polymorphism with increased CRC risk (adjusted OR = 1.44, 95% CI 1.01-2.07, p = 0.02). Stratification analysis showed that the increased risk associated with the variant genotypes (GG+AG) was more evident in male subjects (adjusted OR = 1.48, 95% CI 0.94-2.34, p = 0.03). Compared with the AA genotype, the adjusted OR for the variant genotypes was 1.81 (95% CI 1.08 - 3.05, p = 0.01) among young subjects (age ! 57 years). Among individuals who did not smoke or who smoked lightly, there was a significantly increased risk with the variant genotypes (adjusted OR = 1.66, 95% CI 1.08 - 2.56, p = 0.02). We did not observe a relationship between the AKAP10 polymorphism and other clinicopathological and environmental factors. Conclusions: Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population.
Subject headings and genre
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A-kinase anchoring protein 10
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Polymorphism
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2073A >
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G
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Colorectal cancer
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Zhou, Zong-GuangSichuan University
(author)
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Wang, LingSichuan University
(author)
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Yu, Yong-YangSichuan University
(author)
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Zhang, PengSichuan University
(author)
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Zhang, YiSichuan University
(author)
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Cui, Chang-FuSichuan University
(author)
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Yang, LieSichuan University
(author)
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Li, YuanSichuan University
(author)
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Zhou, BinSichuan University
(author)
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Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45
(author)
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Sichuan UniversityOnkologi
(creator_code:org_t)
Related titles
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In:ONCOLOGY: S. Karger AG76:3, s. 199-2040030-24141423-0232
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Wang, Mo-Jin
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Zhou, Zong-Guang
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Wang, Ling
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Yu, Yong-Yang
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Zhang, Peng
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Zhang, Yi
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Cui, Chang-Fu
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Yang, Lie
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Li, Yuan
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Zhou, Bin
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Sun, Xiao-Feng
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Linköping University