Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls

Assarsson, Malin (author): Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Division of Dermatology and Venereology, Region Jönköping County, Sweden

Söderman, Jan (author): Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Division of Medical Diagnostics, Region Jönköping County, Jönköping, Sweden

Dienus, Olaf (author): Division of Medical Diagnostics, Region Jönköping County, Jönköping, Sweden

Seifert, Oliver (author): Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Division of Dermatology and Venereology, Region Jönköping County, Sweden

(creator_code:org_t)

2020
2020
English.
In: Acta Dermato-Venereologica. - : ACTA DERMATO-VENEREOLOGICA. - 0001-5555 .- 1651-2057. ; 100

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Abstract Subject headings

Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial microbiome of the pharynx and skin of patients with psoriasis compared with healthy controls. Swabs were taken from the pharynx and el-bow skin of 39 patients with psoriasis and 70 controls. Microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. Significant differences were found in alpha and beta diversity in the skin, but not in the pharynx. Significant differences were also found between several phyla and genera in both skin and pharynx. The severity of psoriasis did not correlate with any genera in the pharynx, but with Capnocytophaga, Leptotrichia, Abiotrophia and Tannerella in the skin. The composition of the pharyngeal and skin microbiome may be of importance in the pathogenesis of psoriasis.

By the author/editor: Assarsson, Malin; Söderman, Jan; Dienus, Olaf; Seifert, Oliver

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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