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Cardiovascular risk...
Cardiovascular risk factors and body composition in adults with achondroplasia
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- Fredwall, Svein O. (author)
- Sunnaas Rehabil Hosp, Norway; Univ Oslo, Norway
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- Linge, Jennifer (author)
- Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten,AMRA Med AB, Linkoping, Sweden
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- Dahlqvist Leinhard, Olof, 1978- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,AMRA Med AB, Linkoping, Sweden
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- Kjonigsen, Lisa (author)
- Oslo Univ Hosp, Norway
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- Eggesbo, Heidi Beate (author)
- Oslo Univ Hosp, Norway
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- Weedon-Fekjaer, Harald (author)
- Oslo Univ Hosp, Norway
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- Lidal, Ingeborg Beate (author)
- Sunnaas Rehabil Hosp, Norway
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- Manum, Grethe (author)
- Sunnaas Rehabil Hosp, Norway
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- Savarirayan, Ravi (author)
- Murdoch Childrens Res Inst, Australia; Univ Melbourne, Australia
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- Tonstad, Serena (author)
- Oslo Univ Hosp, Norway
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(creator_code:org_t)
- SPRINGERNATURE, 2021
- 2021
- English.
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In: Genetics in Medicine. - : SPRINGERNATURE. - 1098-3600 .- 1530-0366. ; 23, s. 732-739
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose An increased cardiovascular mortality has been reported in achondroplasia. This population-based, case-control study investigated cardiovascular risk factors and body composition in Norwegian adults with achondroplasia. Methods We conducted anthropometric, clinical, and laboratory assessments in 49 participants with achondroplasia, of whom 40 completed magnetic resonance imaging (MRI) for body composition analysis. Controls consisted of 98 UK Biobank participants, matched for body mass index (BMI), sex, and age. Results Participants were well matched for BMI (33.3 versus 32.5 kg/m(2)) and sex, but achondroplasia participants were younger than controls (mean age 41.1 versus 54.3 years). Individuals with achondroplasia had lower age-adjusted mean blood pressure, total and low-density lipoprotein (LDL) cholesterol, and triglycerides compared with controls, but similar fasting glucose and HbA1c values. Age-adjusted mean visceral fat store was 1.9 versus 5.3 L (difference -2.7, 95% confidence interval [CI] -3.6 to -1.9; P < 0.001), abdominal subcutaneous fat was 6.0 versus 11.2 L (-4.7, 95% CI -5.9 to -3.4; P < 0.001), and liver fat was 2.2 versus 6.9% (-2.8, 95% CI -5.2 to -0.4; P = 0.02). Conclusion Despite a high BMI, the cardiovascular risks appeared similar or lower in achondroplasia compared with controls, indicating that other factors might contribute to the increased mortality observed in this condition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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