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Human G-MDSCs are n...
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Mehmeti-Ajradini, MelihaLund Univ, Sweden
(author)
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-09-21
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LIFE SCIENCE ALLIANCE LLC,2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-172324
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-172324URI
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https://doi.org/10.26508/lsa.202000893DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research CouncilSwedish Research Council [2017 02443]; Swedish Cancer SocietySwedish Cancer Society [18 0693]; National Health Service (ALF); Kocks Foundation; Osterlunds Foundation; Ake Wibergs Foundation; Gyllenstiernska Krapperups foundation; Gunnar Nilsson Cancer Foundation; Malmo Allmanna Sjukhus Cancer Foundation
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Myeloid-derived suppressor cells (MDSCs) are known to contribute to immune evasion in cancer. However, the function of the human granulocytic (G)-MDSC subset during tumor progression is largely unknown, and there are no established markers for their identification in human tumor specimens. Using gene expression profiling, mass cytometry, and tumor microarrays, we here demonstrate that human G-MDSCs occur as neutrophils at distinct maturation stages, with a disease-specific profile. G-MDSCs derived from patients with metastatic breast cancer and malignant melanoma display a unique immature neutrophil profile, that is more similar to healthy donor neutrophils than to G-MDSCs from sepsis patients. Finally, we show that primary G-MDSCs from metastatic breast cancer patients co-transplanted with breast cancer cells, promote tumor growth, and affect vessel formation, leading to myeloid immune cell exclusion. Our findings reveal a role for human G-MDSC in tumor progression and have clinical implications also for targeted immunotherapy.
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Bergenfelz, CarolineLund Univ, Sweden
(author)
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Larsson, Anna-MariaLund Univ, Sweden; Skane Univ Hosp, Sweden
(author)
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Carlsson, RobertLund Univ, Sweden
(author)
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Riesbeck, KristianLund Univ, Sweden
(author)
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Ahl, JonasLund Univ, Sweden
(author)
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Janols, HelenaLund Univ, Sweden
(author)
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Wullt, MarleneLund Univ, Sweden
(author)
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Bredberg, AndersLund Univ, Sweden
(author)
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Kallberg, EvaLund Univ, Sweden
(author)
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Gunnarsdottir, Frida BjorkLund Univ, Sweden
(author)
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Millrud, Camilla RydbergLund Univ, Sweden
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Ryden, LisaLund Univ, Sweden; Skane Univ Hosp, Sweden
(author)
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Paul, GesineLund Univ, Sweden
(author)
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Loman, NiklasLund Univ, Sweden; Skane Univ Hosp, Sweden
(author)
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Adolfsson, JörgenLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)jorad85
(author)
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Carneiro, AnaLund Univ, Sweden; Skane Univ Hosp, Sweden
(author)
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Jirstrom, KarinLund Univ, Sweden
(author)
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Killander, FredrikaLund Univ, Sweden; Skane Univ Hosp, Sweden
(author)
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Bexell, DanielLund Univ, Sweden
(author)
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Leandersson, KarinLund Univ, Sweden
(author)
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Lund Univ, SwedenLund Univ, Sweden; Skane Univ Hosp, Sweden
(creator_code:org_t)
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In:Life Science Alliance: LIFE SCIENCE ALLIANCE LLC3:112575-1077
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Carlsson, Robert
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Riesbeck, Kristi ...
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Ahl, Jonas
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Janols, Helena
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Wullt, Marlene
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Bredberg, Anders
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Ryden, Lisa
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Paul, Gesine
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Loman, Niklas
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