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  • Lee, Keum HwaYonsei Univ, South Korea (author)

Consumption of Fish and omega-3 Fatty Acids and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • OXFORD UNIV PRESS,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-172330
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-172330URI
  • https://doi.org/10.1093/advances/nmaa055DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145379773URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Funding Agencies|US National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R35 CA197735]
  • Multiple studies have suggested that omega-3 fatty acid intake may have a protective effect on cancer risk; however, its true association with cancer risk remains controversial. We performed an umbrella review of meta-analyses to summarize and evaluate the evidence for the association between omega-3 fatty acid intake and cancer outcomes. We searched PubMed, Embase, and the Cochrane Database of Systematic Reviews from inception to December 1, 2018. We included meta-analyses of observational studies that examined associations between intake of fish or omega-3 fatty acid and cancer risk (gastrointestinal, liver, breast, gynecologic, prostate, brain, lung, and skin) and determined the level of evidence of associations. In addition, we appraised the quality of the evidence of significant meta-analyses by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. We initially screened 598 articles, and 15 articles, including 57 meta-analyses, were eligible. Among 57 meta-analyses, 15 reported statistically significant results. We found that 12 meta-analyses showed weak evidence of an association between omega-3 fatty acid intake and risk of the following types of cancer: liver cancer (n = 4 of 6), breast cancer (n = 3 of 14), prostate cancer (n = 3 of 11), and brain tumor (n = 2 of 2). In the other 3 meta-analyses, studies of endometrial cancer and skin cancer, there were no assessable data for determining the evidence levels. No meta-analysis showed convincing, highly suggestive, or suggestive evidence of an association. In the sensitivity analysis of meta analyses by study design, we found weak associations between omega-3 fatty acid intake and breast cancer risk in cohort studies, but no statistically significant association in case-control studies. However, the opposite results were found in case of brain tumor risk. Although omega-3 fatty acids have been studied in several meta-analyses with regard to a wide range of cancer outcomes, only weak associations were identified in some cancer types, with several limitations. Considering the nonsignificant or weak evidence level, clinicians and researchers should cautiously interpret reported associations between omega-3 fatty acid consumption and cancer risks.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Seong, Hyo JinYonsei Univ, South Korea (author)
  • Kim, GaeunKeimyung Univ, South Korea (author)
  • Jeong, Gwang HunGyeongsang Natl Univ, South Korea (author)
  • Kim, Jong YeobYonsei Univ, South Korea (author)
  • Park, HyunbongYonsei Univ, South Korea (author)
  • Jung, EunyoungYonsei Univ, South Korea (author)
  • Kronbichler, AndreasMed Univ Innsbruck, Austria (author)
  • Eisenhut, MichaelLuton & Dunstable Univ Hosp NHS Fdn Trust, England (author)
  • Stubbs, BrendonKings Coll London, England; South London & Maudsley NHS Fdn Trust, England; Anglia Ruskin Univ, England (author)
  • Solmi, MarcoUniv Padua, Italy (author)
  • Koyanagi, AiUniv Barcelona, Spain; ICREA, Spain (author)
  • Hong, Sung HwiYonsei Univ, South Korea; Harvard TH Chan Sch Publ Hlth, MA USA (author)
  • Dragioti, ElenaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum(Swepub:liu)eledr71 (author)
  • Machado de Rezende, Leandro ForniasUniv Fed Sao Paulo, Brazil (author)
  • Jacob, LouisUniv Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France (author)
  • Keum, NaNaHarvard TH Chan Sch Publ Hlth, MA USA; Dongguk Univ, South Korea (author)
  • van der Vliet, Hans J.Vrije Univ Amsterdam, Netherlands (author)
  • Cho, EunyoungBrown Univ, RI 02912 USA; Brigham & Womens Hosp, MA 02115 USA; Harvard Med Sch, MA 02115 USA (author)
  • Veronese, NicolaCNR, Italy (author)
  • Grosso, GiuseppeUniv Catania, Italy (author)
  • Ogino, ShujiHarvard Med Sch, MA 02115 USA; Dana Farber Harvard Canc Ctr, MA USA; Harvard TH Chan Sch Publ Hlth, MA USA; Brigham & Womens Hosp, MA 02115 USA; Broad Inst MIT & Harvard, MA 02142 USA (author)
  • Song, MingyangHarvard TH Chan Sch Publ Hlth, MA USA; Harvard Med Sch, MA 02115 USA; Harvard TH Chan Sch Publ Hlth, MA USA; Massachusetts Gen Hosp, MA 02114 USA; Massachusetts Gen Hosp, MA 02114 USA (author)
  • Radua, JoaquimKarolinska Institutet (author)
  • Jung, Sun JaeHarvard TH Chan Sch Publ Hlth, MA USA; Yonsei Univ, South Korea (author)
  • Thompson, TrevorUniv Greenwich, England (author)
  • Jackson, Sarah E.UCL, England (author)
  • Smith, LeeAnglia Ruskin Univ, England (author)
  • Yang, LinAlberta Hlth Serv, Canada; Univ Calgary, Canada; Univ Calgary, Canada (author)
  • Oh, HansUniv South Carolina, SC 29208 USA (author)
  • Choi, Eun KyoungYonsei Univ, South Korea (author)
  • Shin, Jae IlYonsei Univ, South Korea (author)
  • Giovannucci, Edward L.Harvard TH Chan Sch Publ Hlth, MA USA; Brigham & Womens Hosp, MA 02115 USA; Harvard Med Sch, MA 02115 USA (author)
  • Gamerith, GabrieleMed Univ Innsbruck, Austria (author)
  • Yonsei Univ, South KoreaKeimyung Univ, South Korea (creator_code:org_t)

Related titles

  • In:ADVANCES IN NUTRITION: OXFORD UNIV PRESS11:5, s. 1134-11492161-83132156-5376

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