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Live predator stres...
Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns
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- Tapocik, J. D. (author)
- NIH, MD 20817 USA; NIAAA, MD 20852 USA
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- Schank, J. R. (author)
- NIH, MD 20817 USA; Univ Georgia, GA 30602 USA
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- Mitchell, J. R. (author)
- Colby Coll, ME 04901 USA; Northeastern Univ, MA 02115 USA
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- Damazdic, R. (author)
- NIH, MD 20817 USA
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- Mayo, C. L. (author)
- Univ Maryland, MD 21228 USA
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- Brady, D. (author)
- Univ Maryland, MD 21228 USA
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- Pincus, A. B. (author)
- NIH, MD 20817 USA; Oregon Hlth & Sci Univ, OR 97239 USA
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- King, C. E. (author)
- NIH, MD 20817 USA; Med Univ South Carolina, SC 29425 USA
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- Heilig, Markus (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping,NIH, MD 20817 USA
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- Elmer, G. I. (author)
- Univ Maryland, MD 21228 USA; Univ Maryland, MD 21201 USA
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(creator_code:org_t)
- ELSEVIER, 2021
- 2021
- English.
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In: Behavioural Brain Research. - : ELSEVIER. - 0166-4328 .- 1872-7549. ; 400
- Related links:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Exposure to traumatic events during childhood increases the risk of adult psychopathology, including anxiety, depression, alcohol use disorders and their co-morbidity. Early life trauma also results in increased symptom complexity, treatment resistance and poor treatment outcomes. The purpose of this study was to establish a novel rodent model of adolescent stress, based on an ethologically relevant life-threatening event, live predator exposure. Rats were exposed to a live predator for 10 min. at three different time points (postnatal day (PND)31, 46 and 61). Adult depression-, anxiety-like behaviors and ethanol consumption were characterized well past the last acute stress event (two weeks). Behavioral profiles across assessments were developed to characterize individual response to adolescent stress. CNS activation patterns in separate groups of subjects were characterized after the early (PND31) and last predator exposure (PND61). Subjects exposed to live-predator adolescent stress generally exhibited less exploratory behavior, less propensity to venture into open spaces, a decreased preference for sweet solutions and decreased ethanol consumption in a two-bottle preference test. Additional studies demonstrated blunted cortisol response and CNS activation patterns suggestive of habenula, rostromedial tegmental (RMTg), dorsal raphe and central amygdala involvement in mediating the adult consequences of adolescent stress. Thus, adolescent stress in the form of live-predator exposure results in significant adult behavioral and neurobiological disturbances. Childhood trauma, its impact on neurodevelopment and the subsequent development of mood disorders is a pervasive theme in mental illness. Improving animal models and our neurobiological understanding of the symptom domains impacted by trauma could significantly improve treatment strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Trauma; Depression; Anxiety; Alcohol; Habenula; Rostromedial tegmentum (RMTg)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Tapocik, J. D.
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Schank, J. R.
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Mitchell, J. R.
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Damazdic, R.
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Mayo, C. L.
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Brady, D.
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show more...
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Pincus, A. B.
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King, C. E.
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Heilig, Markus
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Elmer, G. I.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Behavioural Brai ...
- By the university
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Linköping University