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  • Bai, XiangningKarolinska Institutet (author)

Genomic Insights Into Clinical Shiga Toxin-Producing Escherichia coli Strains: A 15-Year Period Survey in Jonkoping, Sweden

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-02-05
  • FRONTIERS MEDIA SA,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-173864
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173864URI
  • https://doi.org/10.3389/fmicb.2021.627861DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145899772URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Scandinavian Society for Antimicrobial Chemotherapy Foundation [SLS884041]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81701977]
  • Shiga toxin-producing Escherichia coli (STEC) are important foodborne pathogens that can cause human infections ranging from asymptomatic carriage to bloody diarrhea (BD) and fatal hemolytic uremic syndrome (HUS). However, the molecular mechanism of STEC pathogenesis is not entirely known. Here, we demonstrated a large scale of molecular epidemiology and in-depth genomic study of clinical STEC isolates utilizing clinical and epidemiological data collected in Region Jonkoping County, Sweden, over a 15-year period. Out of 184 STEC isolates recovered from distinct patients, 55 were from patients with BD, and 129 were from individuals with non-bloody stools (NBS). Five individuals developed HUS. Adults were more associated with BD. Serotypes O157:H7, O26:H11, O103:H2, O121:H19, and O104:H4 were more often associated with BD. The presence of Shiga toxin-encoding gene subtypes stx(2a), stx(2a) + stx(2c), and stx(1a) + stx(2c) was associated with BD, while stx(1)(a) was associated with milder disease. Multiplex virulence and accessory genes were correlated with BD; these genes encode toxins, adhesion, autotransporters, invasion, and secretion system. A number of antimicrobial resistance (AMR) genes, such as aminoglycoside, aminocoumarin, macrolide, and fluoroquinolone resistance genes, were prevalent among clinical STEC isolates. Whole-genome phylogeny revealed that O157 and non-O157 STEC isolates evolved from distinct lineages with a few exceptions. Isolates from BD showed more tendency to cluster closely. In conclusion, this study unravels molecular trait of clinical STEC strains and identifies genetic factors associated with severe clinical outcomes, which could contribute to management of STEC infections and disease progression if confirmed by further functional validation.

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  • Zhang, JiMassey Univ, New Zealand (author)
  • Hua, YingKarolinska Inst, Sweden; Southern Med Univ, Peoples R China (author)
  • Jernberg, CeciliaPubl Hlth Agcy Sweden, Sweden (author)
  • Xiong, YanwenChinese Ctr Dis Control & Prevent, Peoples R China (author)
  • French, NigelMassey Univ, New Zealand (author)
  • Löfgren, StureLinköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Jonkoping Reg Cty, Jonkoping, Sweden(Swepub:liu)n/a (author)
  • Hedenstrom, IngelaPubl Hlth Agcy Sweden, Sweden (author)
  • Ambikan, AnoopKarolinska Institutet (author)
  • Mernelius, SaraLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)sarme88 (author)
  • Matussek, AndreasLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Karolinska Inst, Sweden; Oslo Univ Hosp, Norway; Univ Oslo, Norway(Swepub:liu)andma17 (author)
  • Karolinska InstitutetMassey Univ, New Zealand (creator_code:org_t)

Related titles

  • In:Frontiers in Microbiology: FRONTIERS MEDIA SA121664-302X

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