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- Barchiesi, RiccardoLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten (author)
Stress-induced escalation of alcohol self-administration, anxiety-like behavior, and elevated amygdala Avp expression in a susceptible subpopulation of rats
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-02-09
- Wiley,2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-173908
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173908URI
- https://doi.org/10.1111/adb.13009DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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- Funding Agencies|Wallenberg FoundationEuropean Commission [KAW 2018.0322]; Region Ostergotland; Stiftelsen psykiatriska forskningsfonden; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2013-07434]
- Comorbidity between alcohol use and anxiety disorders is associated with more severe symptoms and poorer treatment outcomes than either of the conditions alone. There is a well-known link between stress and the development of these disorders, with post-traumatic stress disorder as a prototypic example. Post-traumatic stress disorder can arise as a consequence of experiencing traumatic events firsthand and also after witnessing them. Here, we used a model of social defeat and witness stress in rats, to study shared mechanisms of stress-induced anxiety-like behavior and escalated alcohol self-administration. Similar to what is observed clinically, we found considerable individual differences in susceptibility and resilience to the stress. Both among defeated and witness rats, we found a subpopulation in which exposure was followed by emergence of increased anxiety-like behavior and escalation of alcohol self-administration. We then profiled gene expression in tissue from the amygdala, a key brain region in the regulation of stress, alcohol use, and anxiety disorders. When comparing "comorbid" and resilient socially defeated rats, we identified a strong upregulation of vasopressin and oxytocin, and this correlated positively with the magnitude of the alcohol self-administration and anxiety-like behavior. A similar trend was observed in comorbid witness rats. Together, our findings provide novel insights into molecular mechanisms underpinning the comorbidity of escalated alcohol self-administration and anxiety-like behavior.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Beroendelära hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Substance Abuse hsv//eng
- alcohol use disorder; anxiety disorders; comorbidity; social defeat stress; vasopressin; witness stress
Added entries (persons, corporate bodies, meetings, titles ...)
- Chanthongdee, KanatLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Mahidol Univ, Thailand(Swepub:liu)kanch40 (author)
- Domi, EsiLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)esido51 (author)
- Gobbo, FrancescoUniv Edinburgh, Scotland (author)
- Coppola, AndreaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)andco82 (author)
- Asratian, AnnaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)annas44 (author)
- Toivainen, SanneLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)santo26 (author)
- Holm, LovisaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)lovho57 (author)
- Augier, GaëlleLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)gaeau73 (author)
- Xu, LiLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Univ Elect Sci & Technol China, Peoples R China(Swepub:liu)lixu00 (author)
- Augier, EricLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)eriau90 (author)
- Heilig, MarkusLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)marhe41 (author)
- Barbier, EstelleLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)estba07 (author)
- Linköpings universitetCentrum för social och affektiv neurovetenskap (creator_code:org_t)
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