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Effects of Lactobac...
Effects of Lactobacillus reuteri supplementation on the gut microbiota in extremely preterm infants in a randomized placebo-controlled trial
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- Martí Generó, Magalí Martí (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Spreckels, Johanne (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Univ Med Ctr Groningen, Netherlands
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- Ranasinghe, Purnika (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Queens Univ Belfast, North Ireland
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- Wejryd, Erik (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Norrköping
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- Marchini, Giovanna (author)
- Karolinska Univ Hosp & Inst, Sweden
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- Sverremark-Ekström, Eva (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Sweden
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- Jenmalm, Maria (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Abrahamsson, Thomas (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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(creator_code:org_t)
- Cell Press, 2021
- 2021
- English.
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In: Cell Reports Medicine. - : Cell Press. - 2666-3791. ; 2:3
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Abstract
Subject headings
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- Extremely low birth weight (ELBW) infants often develop an altered gut microbiota composition, which is related to clinical complications, such as necrotizing enterocolitis and sepsis. Probiotic supplementation may reduce these complications, and modulation of the gut microbiome is a potential mechanism underlying the probiotic effectiveness. In a randomized, double-blind, placebo-controlled trial, we assessed the effect of Lactobacillus reuteri supplementation, from birth to post-menstrual week (PMW)36, on infant gut microbiota. We performed 16S amplicon sequencing in 558 stool samples from 132 ELBW preterm infants at 1 week, 2 weeks, 3 weeks, 4 weeks, PMW36, and 2 years. Probiotic supplementation results in increased bacterial diversity and increased L. reuteri abundance during the 1st month. At 1 week, probiotic supplementation also results in a lower abundance of Enterobacteriaceae and Staphylococcaceae. No effects were found at 2 years. In conclusion, probiotics may exert benefits by modulating the gut microbiota composition during the 1st month in ELBW infants.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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