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Uninterrupted Oral ...
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Venetsanos, DimitriosKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
(author)
Uninterrupted Oral Anticoagulant Therapy in Patients Undergoing Unplanned Percutaneous Coronary Intervention
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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ELSEVIER SCIENCE INC,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-175704
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175704URI
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https://doi.org/10.1016/j.jcin.2021.01.022DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146478741URI
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https://gup.ub.gu.se/publication/303158URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Boston ScientificBoston Scientific; AbbottAbbott Laboratories; AstraZenecaAstraZeneca; BayerBayer AG
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OBJECTIVES This study sought to compare interrupted and uninterrupted oral anticoagulant therapy (I-OAC vs. U-OAC) in patients on OAC undergoing percutaneous coronary intervention. BACKGROUND There is a paucity of data regarding the optimal peri-procedural management of OAC-treated patients. METHODS In the SWEDEHEART registry, all patients on OAC who were admitted acutely and underwent percutaneous coronary intervention or coronary angiography with a diagnostic procedure, from 2005 to 2017, were included. Outcomes were major adverse cardiac and cerebrovascular events (MACCE; death, myocardial infarction, or stroke) and bleeds at 120 days. Propensity score was used to adjust for the nonrandomized treatment selection. RESULTS The study included 6,485 patients: 3,322 in the I-OAC group and 3,163 in the U-OAC group. The cumulative incidence of MACCE was 8.2% (269 events) versus 8.2% (254 events) in the I-OAC and the U-OAC groups, respectively. The adjusted risk for MACCE did not differ between the groups (I-OAC vs. U-OAC hazard ratio: 0.89; 95% confidence interval: 0.71 to 1.12). Similarly, no difference was found in the risk for MACCE or bleeds (12.6% vs. 12.9%, adjusted hazard ratio: 0.87; 95% confidence interval: 0.70 to 1.07). The risk for major or minor in-hospital bleeds did not differ between the groups. However, U-OAC was associated with a significantly shorter duration of hospitalization: 4 (3 to 7) days versus 5 (3 to 8) days; p < 0.01. CONCLUSIONS I-OAC and U-OAC were associated with equivalent risk for MACCE and bleeding complications. An U-OAC strategy was associated with shorter length of hospitalization. These data support U-OAC as the preferable strategy in patients on OAC undergoing coronary intervention. (c) 2021 by the American College of Cardiology Foundation.
Subject headings and genre
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Skibniewski, MikolajLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)miksk98
(author)
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Janzon, Magnus,1961-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)magja75
(author)
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Sederholm Lawesson, SofiaLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)sofla80
(author)
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Charitakis, EmmanouilLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)emmch01
(author)
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Boehm, FelixKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
(author)
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Henareh, LoghmanKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
(author)
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Andell, PontusKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
(author)
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Karlsson, Lars O.Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)larka64
(author)
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Simonsson, MoaKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
(author)
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Völz, Sebastian,1980Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xvolse
(author)
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Erlinge, DavidLund Univ Hosp, Sweden
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Omerovic, Elmir,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xomeel
(author)
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Alfredsson, Joakim,1962-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)joaal38
(author)
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Karolinska InstitutetKarolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
(creator_code:org_t)
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In:JACC: ELSEVIER SCIENCE INC14:7, s. 754-7631936-87981876-7605
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