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  • Simpson, Fiona C.Hop Maison Neuve Rosemont, Canada; Univ Montreal, Canada; Univ Montreal, Canada; Ctr Hosp Univ Montreal, Canada (author)

Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-05-21
  • Nature Research,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-177457
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-177457URI
  • https://doi.org/10.1038/s42003-021-02108-yDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|DBT-Vinnova Indo-Swedish strategic cooperative grant [AB16-07, DNR 2013-04645]; CIHRCanadian Institutes of Health Research (CIHR) [391487]; Fonds de recherche en ophtalmologie de lUniversite de Montreal (FROUM); Caroline Durand Foundation Research Chair for Cellular Therapy in the Eye; Natural Sciences and Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada (NSERC); U.K. Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MR/S037829/1]; ISCIIIInstituto de Salud Carlos III [ICI19/00006]; ERDF/ESF; DBT-Vinnova Indo-Swedish grant
  • The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection is heightened. Here, we show that bioengineered, fully synthetic, and robust corneal implants can be manufactured from a collagen analog (collagen-like peptide-polyethylene glycol hybrid, CLP-PEG) and inflammation-suppressing polymeric 2-methacryloyloxyethyl phosphorylcholine (MPC) when stabilized with the triazine-based crosslinker 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The resulting CLP-PEG-MPC implants led to reduced corneal swelling, haze, and neovascularization in comparison to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. Implants incorporating MPC allowed for faster nerve regeneration and recovery of corneal sensation. CLP-PEG-MPC implants appear to be at a more advanced stage of regeneration than the CLP-PEG only implants, as evidenced by the presence of higher amounts of cornea-specific type V collagen, and a corresponding decrease in the presence of extracellular vesicles and exosomes in the corneal stroma, in keeping with the amounts present in healthy, unoperated corneas. Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study suggests the superiority of CLP-PEG-MPC implants over the CLP-PEG only implants.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • McTiernan, Christopher D.Univ Ottawa, Canada (author)
  • Islam, Mohammad MirazulHarvard Med Sch, MA 02115 USA; Harvard Med Sch, MA 02115 USA (author)
  • Buznyk, OleksiyLinköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US,NAMS Ukraine, Ukraine(Swepub:liu)olebu51 (author)
  • Lewis, Philip N.Cardiff Univ, Wales (author)
  • Meek, Keith M.Cardiff Univ, Wales (author)
  • Haagdorens, MichelUniv Antwerp, Belgium (author)
  • Audiger, CindyHop Maison Neuve Rosemont, Canada; Univ Montreal, Canada (author)
  • Lesage, SylvieHop Maison Neuve Rosemont, Canada; Univ Montreal, Canada (author)
  • Gueriot, Francois-XavierHop Maison Neuve Rosemont, Canada; Valence Hosp, France (author)
  • Brunette, IsabelleHop Maison Neuve Rosemont, Canada; Univ Montreal, Canada (author)
  • Robert, Marie-ClaudeHop Maison Neuve Rosemont, Canada; Ctr Hosp Univ Montreal, Canada (author)
  • Olsen, DavidFibroGen Inc, CA USA (author)
  • Koivusalo, LauraTampere Univ, Finland (author)
  • Liszka, AnetaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)aneli97 (author)
  • Fagerholm, PerLinköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US(Swepub:liu)perfa04 (author)
  • Gonzalez-Andrades, MiguelHarvard Med Sch, MA 02115 USA; Harvard Med Sch, MA 02115 USA; Reina Sofia Univ Hosp, Spain; Univ Cordoba, Spain (author)
  • Griffith, MayHop Maison Neuve Rosemont, Canada; Univ Montreal, Canada; Univ Montreal, Canada; Ctr Hosp Univ Montreal, Canada (author)
  • Hop Maison Neuve Rosemont, Canada; Univ Montreal, Canada; Univ Montreal, Canada; Ctr Hosp Univ Montreal, CanadaUniv Ottawa, Canada (creator_code:org_t)

Related titles

  • In:Communications Biology: Nature Research4:12399-3642

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